Current Treatment Options in Oncology

, Volume 7, Issue 4, pp 261–269 | Cite as

Gene expression signatures and outcome prediction in mature B-cell malignancies

  • Sandeep S. Dave
Article

Opinion statement

Non-Hodgkin's lymphomas comprise a diverse group of diseases that are subclassified by the state of differentiation of the malignant B cells, presence of specific cytogenetic abnormalities, and characteristic morphology. Gene expression profiling has revealed that within each category of non-Hodgkin's lymphoma, there exists a significant molecular heterogeneity that can be reflected in differences in tumor behavior and patient outcome. Appreciation of gene expression signatures that are associated with patient outcome will allow better prognostication of disease course and aid the application of molecularly selective patients to improve patient outcome.

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Copyright information

© Current Science Inc 2006

Authors and Affiliations

  • Sandeep S. Dave
    • 1
  1. 1.National Cancer InstituteBethesdaUSA

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