Gene expression signatures and outcome prediction in mature B-cell malignancies
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Non-Hodgkin's lymphomas comprise a diverse group of diseases that are subclassified by the state of differentiation of the malignant B cells, presence of specific cytogenetic abnormalities, and characteristic morphology. Gene expression profiling has revealed that within each category of non-Hodgkin's lymphoma, there exists a significant molecular heterogeneity that can be reflected in differences in tumor behavior and patient outcome. Appreciation of gene expression signatures that are associated with patient outcome will allow better prognostication of disease course and aid the application of molecularly selective patients to improve patient outcome.
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References and Recommended Reading
- 7.Rosenwald A, Wright G, Chan WC, et al.: The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 2002, 346:1937–1947. Comprehensive description of gene expression signatures that distinguish prognostic subgroups within DLBCL.PubMedCrossRefGoogle Scholar
- 9.Lossos IS, Czerwinski DK, Alizadeh AA, et al.: Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes. N Engl J Med 2004, 350:1828–1837. Independent validation of findings from the study by Rosenwald et al.  and identification of a smaller gene set that can be used to predict prognosis in DLBCL.PubMedCrossRefGoogle Scholar
- 14.Winter JN, Weller EA, Horning SJ, et al.: Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study. Blood 2006, In press.Google Scholar
- 18.Dave SS, Wright G, Tan B, et al.: Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med 2004, 351:2159–2169. Demonstration of effects of nonmalignant cells in predicting long-term survival in patients with follicular lymphoma.PubMedCrossRefGoogle Scholar
- 20.Rosenwald A, Wright G, Wiestner A, et al.: The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 2003, 3:185–197. Demonstration of the proliferation gene expression signature and its association with survival as well as several independent oncogenic events.PubMedCrossRefGoogle Scholar
- 23.Savage KJ, Monti S, Kutok JL, et al.: The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood 2003, 102:3871–3879. Demonstration of a distinct subgroup of DLBCL with a distinctive gene expression profile.PubMedCrossRefGoogle Scholar
- 24.Rosenwald A, Wright G, Leroy K, et al.: Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med 2003, 198:851–862. Demonstration of a distinct subgroup of DLBCL with a distinctive gene expression profile.PubMedCrossRefGoogle Scholar