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Current Treatment Options in Oncology

, Volume 4, Issue 5, pp 385–390 | Cite as

Metastatic renal cell carcinoma

  • Robert C. Flanigan
  • Steven C. Campbell
  • Joseph I. Clark
  • Maria M. Picken
Article

Opinion statement

Patients with renal cell cancer (RCC) develop metastatic spread in approximately 33% of cases. The clinical management of patients with metastatic RCC is complicated by the lack of significant efficacy from available therapies. Common sites of metastases include the lung, liver, bone, brain, and adrenal gland, with case reports detailing the capacity of RCC to appear almost anywhere in the body. More than one organ system is often involved in the metastatic process. Metastases may be found at diagnosis or at some interval after nephrectomy. Approximately 20% to 50% of patients will eventually develop metastatic disease after nephrectomy. A shorter interval between nephrectomy and the development of metastases is associated with a poorer prognosis. Patients with metastatic RCC face a dismal prognosis, with a median survival time of only 6 to 12 months and a 2-year survival rate of 10% to 20%. Recent advances in biologic response modifier therapy have brought new hope to a small percentage of patients who respond to this therapy and rekindled interest in cytoreductive nephrectomy as an integral part of the management of these patients.

Keywords

Vascular Endothelial Growth Factor Renal Cell Carcinoma Renal Cell Cancer Metastatic Renal Cell Carcinoma Flavopiridol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Current Science Inc 2003

Authors and Affiliations

  • Robert C. Flanigan
    • 1
  • Steven C. Campbell
  • Joseph I. Clark
  • Maria M. Picken
  1. 1.Department of UrologyLoyola University Medical Center, Cardinal Bernardin Cancer Center and Hines VA HospitalMaywoodUSA

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