Comprehensive evaluation of irisin levels in fetomaternal circulation of pregnant women with obesity or gestational diabetes mellitus

  • Ali SevenEmail author
  • Esin Yalinbas
  • Suna Kabil Kucur
  • Emel Kocak
  • Ozben Isiklar
  • Beril Yuksel
  • Hakan Timur
  • Mehmet Erbakirci
  • Nadi Keskin
Original Article



To evaluate maternal and cord blood irisin levels in pregnant women with gestational diabetes mellitus (GDM) and in obese pregnant women without GDM.


The study included 109 patients, with 34 patients in the GDM group, 40 in the obese non-GDM group, and 35 in the control group. Maternal serum irisin levels at the time of delivery were measured by an enzyme-linked immunosorbent assay kit. The correlation of serum irisin levels with metabolic parameters and anthropometric measurements was analyzed.


There were significant differences between the study groups in terms of cord arterial, cord venous, and maternal serum irisin levels (P < 0.001, P < 0.01, P < 0.001, respectively). Cord arterial, cord venous, and maternal serum irisin levels were higher in the obese group compared to the control (P < 0.01, P < 0.01, P < 0.01, respectively) and the GDM group (P < 0.001, P < 0.001, P < 0.001, respectively).


Elevation in irisin levels of women who have pregnancies complicated with obesity may be explained as part of the compensation mechanism against disturbed metabolic functions. Pregnant individuals with GDM have lower serum irisin levels in comparison to healthy pregnant women. In this regard, it is possible that the measurement of serum irisin levels may be utilized in the future for prediction, prevention, and treatment of GDM.


Gestational diabetes mellitus Irisin Obesity Pregnancy 


Compliance with ethical standards

The study was performed in accordance with the Declaration of Helsinki. Ethical committee approval was received from the local Human Research Ethics Committee (issue number: 2015-KAEK-86/10). Written informed consent was obtained from all volunteers.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Royal Academy of Medicine in Ireland 2019

Authors and Affiliations

  • Ali Seven
    • 1
    Email author
  • Esin Yalinbas
    • 2
  • Suna Kabil Kucur
    • 1
  • Emel Kocak
    • 3
  • Ozben Isiklar
    • 4
  • Beril Yuksel
    • 1
  • Hakan Timur
    • 5
  • Mehmet Erbakirci
    • 1
  • Nadi Keskin
    • 1
  1. 1.Department of Obstetrics and Gynecology KutahyaDumlupinar University School of MedicineKütahyaTurkey
  2. 2.Department of Pediatrics KutahyaDumlupinar University School of MedicineKütahyaTurkey
  3. 3.Department of Biochemistry KutahyaDumlupinar University School of MedicineKütahyaTurkey
  4. 4.Department of Biochemistry KutahyaDumlupinar University Kutahya Evliya Celebi Training and Research HospitalKütahyaTurkey
  5. 5.Department of Obstetrics and Gynecology AnkaraZekai Tahir Burak Women’s Health Training and Research HospitalKütahyaTurkey

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