Irish Journal of Medical Science (1971 -)

, Volume 187, Issue 4, pp 1133–1137 | Cite as

Festschrift for Ronan O’Connell: pouchitis, ulcerative colitis and the microbiome

  • Aonghus Lavelle
Review Article


The hypothesis of altered bacterial communities contributing to the development of pouchitis began a scientific quest to link host mucosal factors, microbial metabolism and spatial structure of the colonic microbiome in ulcerative colitis, reaching its apotheosis with the integration of advanced spatial sampling with laser capture microdissection, mucin array profiling, molecular microbiology and next-generation sequencing technologies. This article, part of a festschrift, summarises the contributions of the O’Connell lab to the field of host-microbial interactions in inflammatory bowel disease.


Inflammatory bowel disease Microbiome Pouchitis 


Compliance with ethical standards

Conflict of interest

The author declares no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by the author.


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Copyright information

© Royal Academy of Medicine in Ireland 2018

Authors and Affiliations

  1. 1.Department of Medicine, APC Microbiome IrelandUniversity College CorkCorkIreland

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