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Obstetric outcomes of recurrent pregnancy loss patients diagnosed wıth inherited thrombophilia

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Abstract

Background

Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies. The relation between RPL and inherited thrombophilia requires anticoagulant therapy during pregnancy. However the obstetric outcomes have not been well defined in these RPL patients diagnosed with inherited thrombophilia, who have been given anticoagulant therapy.

Aim

To investigate the obstetric outcomes in pregnant women with RPL who are given low molecular weight heparin (LMWH) and low-dose aspirin due to diagnosis of inherited thrombophilia.

Methods

A hundred and eight RPL women were diagnosed with inherited thrombophilia, and 98 women were diagnosed with unexplained RPL. The patients with inherited thrombophilia were given LMWH and low-dose aspirin. Unexplained RPL patients were not given any medicine. The obstetric outcomes of participants were noted.

Results

In thrombophilic group, the live-birth levels were significantly higher [90 (83%) vs 67 (68%) p < 0.05], and the miscarriage levels were significantly lower than that in the control group [14 (13%) vs 27 (28%) p < 0.01]. The number of patients with preeclampsia was significantly higher in the thrombophilic group [16 (15%) vs 6 (6%) p < 0.05]. The number of preterm births was significantly higher than that of the controls [25 (23%) vs 10 (10%) p < 0.05]. The median gestation age of delivery was 35 weeks for thrombophilic patients and 38 weeks for controls (p < 0.05).

Conclusion

The RPL patients diagnosed with inherited thrombophilia and who were given LMWH with low-dose aspirin had higher live-birth rates and lower miscarriage rates than those in the unexplained RPL patients. Increased risk of preeclampsia is seen in RPL patients with inherited thrombophilia despite thrombophilia prophylaxis.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Marmara University School of Medicine, İstanbul, Turkey

    C. Karadağ, T. Yoldemir & L. Aslanova

  2. Department of Obstetrics and Gynecology, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey

    S. D. Karadağ

  3. Department of Obstetrics and Gynecology, Trakya University, Edirne, Turkey

    C. İnan & Z. N. Dolgun

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  1. C. Karadağ
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  2. T. Yoldemir
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  3. S. D. Karadağ
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  4. C. İnan
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Correspondence to C. Karadağ.

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This article does not contain any studies with animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Karadağ, C., Yoldemir, T., Karadağ, S.D. et al. Obstetric outcomes of recurrent pregnancy loss patients diagnosed wıth inherited thrombophilia. Ir J Med Sci 186, 707–713 (2017). https://doi.org/10.1007/s11845-017-1569-0

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  • DOI: https://doi.org/10.1007/s11845-017-1569-0

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