Screening for asymptomatic urogenital Chlamydia trachomatis infection at a large Dublin maternity hospital: results of a pilot study
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There are currently no Irish guidelines on screening for Chlamydia trachomatis infection in pregnancy. Prevalence rates in the antenatal population are not known which has prevented the development of screening recommendations for this group.
The objective of this study was to determine the prevalence of asymptomatic urogenital C. trachomatis infection in young women attending for care at a large maternity hospital.
All patients aged 25 years and under attending the Hospital between December 2011 and December 2013 were offered screening for urogenital C. trachomatis infection. Nucleic acid amplification testing of the C. trachomatis cryptic plasmid was performed on either endocervical swabs or first void urine samples.
There were 2687 women tested for C. trachomatis infection, 83.4 % (2241/2687) through the antenatal clinics, 7.1 % (193/2687) through the gynaecology clinic, and 9.4 % (253/2687) through the emergency department. The rate of a positive test result was 5.6 % (151/2687) overall. The rates in women ages 16–18, 19–21 and 22–25 years were 9.1 % (31/340), 6.5 % (50/774) and 4.4 % (69/1561), respectively. A positive test result was more likely in those who were unemployed (p = 0.04), those who were Irish (p = 0.03) and those who were unmarried (p < 0.01). There were no cases of neonatal C. trachomatis infection in babies born to mothers who were screened in early pregnancy.
The prevalence rate of detected C. trachomatis infection was 5.6 % in the study population. Screening of antenatal patients may have a role in preventing vertical transmission of infection to the neonate.
KeywordsChlamydia trachomatis Antenatal screening Chlamydia trachomatis prevalence
Compliance with ethical standards
No funding was received for this work.
Conflict of interest
AOH declares that she has no conflict of interest. VJ declares that she has no conflict of interest. ML declares that she has no conflict of interest. DLB declares that he has no conflict of interest. GC declares that she has no conflict of interest. ME declares that she has no conflict of interest. JSL declares that he has no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 1.Health Protection Surveillance Centre, Health Services Executive (2011) Trends in Sexually Transmitted Infection (STI) notifications, 1995–2009. Health Services Executive, DublinGoogle Scholar
- 2.Health Protection Surveillance Centre, Health Services Executive (2012) Quarterly report in sexually transmitted infections in Ireland, 2011, quarter 4. Health Services Executive, DublinGoogle Scholar
- 3.European Centre for Disease Prevention and Control (2009) Chlamydia control in Europe. European Centre for Disease Prevention and Control, StockholmGoogle Scholar
- 4.Health Protection Surveillance Centre, Health Services Executive (2005) The need for Chlamydia screening in Ireland. Health Services Executive, DublinGoogle Scholar
- 6.Thorne C (2011) Chlamydia screening in pregnancy: an evidence review. UK National Screening Committee Policy Review, LondonGoogle Scholar
- 8.Rotunda Hospital (2015) Annual clinical report 2014. Rotunda Hospital, DublinGoogle Scholar
- 11.Health Protection Surveillance Centre and Health Research Board (2012) Chlamydia screening in Ireland: a pilot study if opportunistic screening for genital Chlamydia trachomatis infection in Ireland (2007–2009). Health Research Board, DublinGoogle Scholar
- 12.O’Connell E, Brennan W, Cormican M et al (2009) Chlamydia trachomatis infection and sexual behaviour among female students attending higher education in the Republic of Ireland. Pub Health 9:397–403Google Scholar
- 14.National Chlamydia Screening Programme (2013) Annual Chlamydia diagnosis rate. National Chlamydia Screening Programme, LondonGoogle Scholar
- 15.World Health Organization (2011) Prevalence and incidence of selected sexually transmitted infections, Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis and Trichomonas vaginalis: methods and results used by WHO to generate 2005 estimates. World Health Organization, GenevaGoogle Scholar
- 22.Herzog SA, Althaus CL, Heijne JCM et al (2012) Timing of progression of Chlamydia trachomatis infection to pelvic inflammatory disease: a mathematical modelling study. Infect Dis 12:187–195Google Scholar