Irish Journal of Medical Science (1971 -)

, Volume 185, Issue 3, pp 699–704 | Cite as

Propofol-ketamine combination: a choice with less complications and better hemodynamic stability compared to propofol? On a prospective study in a group of colonoscopy patients

  • Z. Baykal Tutal
  • H. Gulec
  • N. Derelı
  • M. Babayıgıt
  • A. Kurtay
  • H. Inceoz
  • E. Horasanlı
Original Article
First Online:
Received:
Accepted:

Abstract

Background and aims

In this study, we compared duration for reaching desired Ramsay Sedation Score (RSS) and postoperative recovery according to Modified Aldrete Score (MAS) of propofol and propofol-ketamine combination in a group of colonoscopy patients. Rates of cardiovascular, respiratory, laryngospasm, visual and nausea/vomiting complications were also compared as secondary outcomes.

Methods

This is a double-blinded prospective randomized controlled trial. 95 patients were included and blocked randomized to either propofol (GroupP, n: 47) or propofol-ketamine (GroupPK, n: 48). GroupP patients received 0.5 mg/kg propofol and GroupPK received 0.5 mg/kg ketamine-propofol. Subjects were monitorized noninvasively preoperatively and every 5 min during procedure. RSS was recorded for every minute before starting procedure and for every 5 min during procedure. Recovery after colonoscopy was evaluated according to MAS. Same observer checked for MAS just after procedure in postoperative 1 min and for every 3 min during follow-up. Postoperative respiratory depression was defined as rate <10/min, hypercapnia/hypercarbia—arterial CO2 tension >50 mmHg or SO2 <90 while hypotension was defined as a decrease of 20 % in mean blood pressure compared to initial values.

Results

GroupPK patients needed shorter duration for achieving RSS ≥ 4 (p: 0.038) but longer duration for achieving MAS ≥ 9 (p: 0.005). GroupP’s intraoperative blood pressures and heart rates were significantly lower compared to initial values. We observed that respiratory depression (19.1 vs 0 %, p: 0.001), hypotension (29.8 vs 10.4 %, p: 0.018), and nausea/vomiting (17 vs 4.2 %, p: 0.041) were significantly more common in GroupP.

Conclusion

Propofol-ketamine combination is an advantageous choice in means of achieving sedation in a shorter period of time, a better hemodynamic stability, less nausea and vomiting and respiratory complication rates. Yet it seems that this choice might be related with longer recovery duration.

Keywords

Propofol Ketamine Sedation Colonoscopy 
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Copyright information

© Royal Academy of Medicine in Ireland 2015

Authors and Affiliations

  • Z. Baykal Tutal
    • 1
  • H. Gulec
    • 1
  • N. Derelı
    • 1
  • M. Babayıgıt
    • 1
  • A. Kurtay
    • 1
  • H. Inceoz
    • 1
  • E. Horasanlı
    • 1
  1. 1.Departments of Anesthesiology and ReanimationKecioren Training and Research HospitalAnkaraTurkey

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