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Irish Journal of Medical Science (1971 -)

, Volume 185, Issue 3, pp 683–687 | Cite as

Correction of vitamin D deficiency in a cohort of newborn infants using daily 200 IU vitamin D supplementation

  • C. Onwuneme
  • B. Diya
  • O. Uduma
  • R. A. McCarthy
  • N. Murphy
  • M. T. Kilbane
  • M. J. McKenna
  • E. J. Molloy
Original Article

Abstract

Introduction

Although the role of vitamin D in the prevention of rickets has long been well established, controversies still exist on the ideal dose of vitamin D supplementation in infants.

Objective

We assessed serum 25-hydroxyvitamin D (25OHD) status simultaneously in maternal and cord samples and the response to vitamin D3 supplementation in neonates.

Methods

Serum 25OHD levels were evaluated from maternal, and umbilical cord samples from term normal pregnancies. Repeat 25OHD levels were assessed in neonates with 25OHD below 30 nmol/L following vitamin D3 200 IU daily after 6 weeks.

Results

Blood samples were taken including 57 cord samples and 16 follow-up neonatal samples. Maternal and cord serum 25OHD were 43 ± 21 and 29 ± 15 nmol/L, respectively. Infants with 25OHD < 30 nmol/L (19.8 ± 4.7 nmol/L) had a significant increase in serum 25OHD (63.3 ± 14.5 nmol/L) following vitamin D3 200 IU daily after 6 weeks.

Conclusion

Healthy Irish infants born at term are at high risk of vitamin D deficiency, but vitamin D3 200 IU daily, rapidly corrects poor vitamin D status.

Keywords

Vitamin D Supplementation Term infants Neonates 

Notes

Compliance with ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of interest

The authors declare no conflict of interest.

Funding

National Maternity Hospital Fund.

References

  1. 1.
    Wagner CL, Greer FR (2008) Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics 122:1142–1152. doi: 10.1542/peds.2008-1862 CrossRefPubMedGoogle Scholar
  2. 2.
    Misra M, Pacaud D, Petryk A et al (2008) Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 122:398–417. doi: 10.1542/peds.2007-1894 CrossRefPubMedGoogle Scholar
  3. 3.
    Walker V, Modlin R (2009) The vitamin D connection to pediatric infections and immune function. Pediatr Res 65:106R–113R. doi: 10.1203/PDR.0b013e31819dba91 CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    McKenna MJ (1992) Differences in vitamin D status between countries in young adults and the elderly. Am J Med 93:69–77CrossRefPubMedGoogle Scholar
  5. 5.
    Holick MF, Chen TC (2008) Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87:1080S–1086SPubMedGoogle Scholar
  6. 6.
    Ireland H (2010) Vitamin D Supplementation for Infants. http://www.hse.ie/eng/health/child/vitaminD/supplementation.html
  7. 7.
    Ross AC, Manson JE, Abrams SA et al (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53–58. doi: 10.1210/jc.2010-2704 CrossRefPubMedGoogle Scholar
  8. 8.
    Luxwolda MF, Kuipers RS, Kema IP et al (2012) Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l. Br J Nutr 108:1557–1561. doi: 10.1017/S0007114511007161 CrossRefPubMedGoogle Scholar
  9. 9.
    McCarthy RA, McKenna MJ, Oyefeso O et al (2012) Vitamin D nutritional status in preterm infants and response to supplementation. Br J Nutr. doi: 10.1017/S0007114512004722 PubMedGoogle Scholar
  10. 10.
    McCarthy RA, McKenna MJ, Oyefeso O et al (2012) Vitamin D nutritional status in preterm infants and response to supplementation. Br J Nutr. doi: 10.1017/S0007114512004722 PubMedGoogle Scholar
  11. 11.
    Carter GD (2009) 25-Hydroxyvitamin D assays: the quest for accuracy. Clin Chem 55:1300–1302. doi: 10.1373/clinchem.2009.125906 CrossRefPubMedGoogle Scholar
  12. 12.
    Walsh JM, Kilbane M, McGowan CA et al (2013) Pregnancy in dark winters: implications for fetal bone growth? Fertil Steril 99:206–211. doi: 10.1016/j.fertnstert.2012.09.010 CrossRefPubMedGoogle Scholar
  13. 13.
    Canadian Paediatric Society (2007) Vitamin D supplementation: recommendations for Canadian mothers and infants. Paediatr Child Health 12:583–598Google Scholar
  14. 14.
    Holick M, Binkley N (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. Clin Endocrinol 96:1911–1930. doi: 10.1210/jc.2011-0385 CrossRefGoogle Scholar
  15. 15.
    Agostoni C, Buonocore G, Carnielli VP et al (2010) Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 50:85–91. doi: 10.1097/MPG.0b013e3181adaee0 CrossRefPubMedGoogle Scholar
  16. 16.
    Shakiba M, Sadr S, Nefei Z et al (2010) Combination of bolus dose vitamin D with routine vaccination in infants: a randomised trial. Singapore Med J 51:440–445PubMedGoogle Scholar
  17. 17.
    Siafarikas A, Piazena H, Feister U et al (2011) Randomised controlled trial analysing supplementation with 250 versus 500 units of vitamin D3, sun exposure and surrounding factors in breastfed infants. Arch Dis Child 96:91–95. doi: 10.1136/adc.2009.178301 CrossRefPubMedGoogle Scholar

Copyright information

© Royal Academy of Medicine in Ireland 2015

Authors and Affiliations

  • C. Onwuneme
    • 1
    • 2
    • 3
  • B. Diya
    • 1
  • O. Uduma
    • 1
  • R. A. McCarthy
    • 1
  • N. Murphy
    • 2
  • M. T. Kilbane
    • 4
  • M. J. McKenna
    • 3
    • 4
  • E. J. Molloy
    • 1
    • 3
    • 5
    • 6
    • 7
    • 8
  1. 1.Department of NeonatologyNational Maternity HospitalDublinIreland
  2. 2.Department of PaediatricsChildren’s University HospitalDublinIreland
  3. 3.Department of Medicine & Medical SciencesUniversity College DublinDublinIreland
  4. 4.Department of Metabolism and EndocrinologySt Vincent’s University HospitalDublinIreland
  5. 5.Department of Paediatrics, Department of PaediatricsRoyal College of Surgeons of IrelandDublinIreland
  6. 6.Department of NeonatologyOur Lady’s Children’s HospitalDublin 12Ireland
  7. 7.Department of PaediatricsTrinity College DublinDublinIreland
  8. 8.Department of Paediatrics, Trinity Centre for Health SciencesAdelaide and Meath Hospital Dublin incorporating The National Children’s Hospital (AMNCH)Dublin 24Ireland

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