Irish Journal of Medical Science (1971 -)

, Volume 185, Issue 3, pp 683–687 | Cite as

Correction of vitamin D deficiency in a cohort of newborn infants using daily 200 IU vitamin D supplementation

  • C. Onwuneme
  • B. Diya
  • O. Uduma
  • R. A. McCarthy
  • N. Murphy
  • M. T. Kilbane
  • M. J. McKenna
  • E. J. Molloy
Original Article



Although the role of vitamin D in the prevention of rickets has long been well established, controversies still exist on the ideal dose of vitamin D supplementation in infants.


We assessed serum 25-hydroxyvitamin D (25OHD) status simultaneously in maternal and cord samples and the response to vitamin D3 supplementation in neonates.


Serum 25OHD levels were evaluated from maternal, and umbilical cord samples from term normal pregnancies. Repeat 25OHD levels were assessed in neonates with 25OHD below 30 nmol/L following vitamin D3 200 IU daily after 6 weeks.


Blood samples were taken including 57 cord samples and 16 follow-up neonatal samples. Maternal and cord serum 25OHD were 43 ± 21 and 29 ± 15 nmol/L, respectively. Infants with 25OHD < 30 nmol/L (19.8 ± 4.7 nmol/L) had a significant increase in serum 25OHD (63.3 ± 14.5 nmol/L) following vitamin D3 200 IU daily after 6 weeks.


Healthy Irish infants born at term are at high risk of vitamin D deficiency, but vitamin D3 200 IU daily, rapidly corrects poor vitamin D status.


Vitamin D Supplementation Term infants Neonates 


Compliance with ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of interest

The authors declare no conflict of interest.


National Maternity Hospital Fund.


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Copyright information

© Royal Academy of Medicine in Ireland 2015

Authors and Affiliations

  • C. Onwuneme
    • 1
    • 2
    • 3
  • B. Diya
    • 1
  • O. Uduma
    • 1
  • R. A. McCarthy
    • 1
  • N. Murphy
    • 2
  • M. T. Kilbane
    • 4
  • M. J. McKenna
    • 3
    • 4
  • E. J. Molloy
    • 1
    • 3
    • 5
    • 6
    • 7
    • 8
  1. 1.Department of NeonatologyNational Maternity HospitalDublinIreland
  2. 2.Department of PaediatricsChildren’s University HospitalDublinIreland
  3. 3.Department of Medicine & Medical SciencesUniversity College DublinDublinIreland
  4. 4.Department of Metabolism and EndocrinologySt Vincent’s University HospitalDublinIreland
  5. 5.Department of Paediatrics, Department of PaediatricsRoyal College of Surgeons of IrelandDublinIreland
  6. 6.Department of NeonatologyOur Lady’s Children’s HospitalDublin 12Ireland
  7. 7.Department of PaediatricsTrinity College DublinDublinIreland
  8. 8.Department of Paediatrics, Trinity Centre for Health SciencesAdelaide and Meath Hospital Dublin incorporating The National Children’s Hospital (AMNCH)Dublin 24Ireland

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