The double-edged sword of vitamin D in Ireland: the need for public health awareness about too much as well as too little
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The Institute of Medicine (IOM) 2011 on dietary references intakes for calcium and vitamin D specified that a 25-hydroxyvitamin D (25OHD) level below 30 nmol/L indicated risk of deficiency and that a level above 125 nmol/L indicated risk of harm.
We noted a high prevalence of hypovitaminosis D (23.9 %) and a substantive prevalence of hypervitaminosis D (4.8 %) in a retrospective audit of clinical samples (n = 10,181) obtained over 10 months in 2013.
Hypovitaminosis D should be corrected by low dose supplementation (5 µg or 200 IU daily) with some at-risk groups needing higher doses (10 µg or 400 IU daily) based on 25OHD levels. Whereas, those taking high-dose vitamin D supplements based on mistaken beliefs about recently authorised claims of benefit for muscle function and misleading unauthorised claims need to be alerted to the potential harms of excessive supplementation.
KeywordsVitamin D Institute of Medicine Audit
Conflict of interest
Dr. Kilbane has nothing to disclose.
- 2.Committee to review dietary reference intakes for vitamin D and calcium, Institute of Medicine (2011) In: Ross AC, Taylor CL, Yaktine AL, Valle HBD (eds) Dietary reference intakes for calcium and vitamin D. The National Academies Press, USAGoogle Scholar