Irish Journal of Medical Science (1971 -)

, Volume 183, Issue 3, pp 477–480 | Cite as

Placental prothrombin mRNA levels in APC resistance (APCR) women with increased placental fibrin deposition

  • S. Sedano-Balbas
  • M. Lyons
  • B. Cleary
  • M. Murray
  • G. Gaffney
  • M. Maher
Brief Report

Abstract

We investigated the link between the mRNA of the procoagulant prothrombin in the placental tissue with the increased placental fibrin deposition associated with activated protein C resistance (APCR). Women with APCR were not found to produce higher levels of prothrombin transcript compared to women with a normal APC ratio. This indicates that accumulated fibrin in the placenta is not the consequence of too much production of the procoagulant prothrombin transcript, but may be associated with altered function of other haemostatic factors interacting with APC in the placenta.

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Copyright information

© Royal Academy of Medicine in Ireland 2013

Authors and Affiliations

  • S. Sedano-Balbas
    • 1
  • M. Lyons
    • 2
  • B. Cleary
    • 2
  • M. Murray
    • 2
  • G. Gaffney
    • 3
  • M. Maher
    • 1
  1. 1.Molecular Diagnostics Research Group, National Centre for Biomedical Engineering Science, National Diagnostics CentreNational University of IrelandGalwayIreland
  2. 2.Department of HaematologyUniversity College Hospital GalwayGalwayIreland
  3. 3.Department of Obstetrics and GynaecologyUniversity College Hospital GalwayGalwayIreland

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