Irish Journal of Medical Science

, Volume 182, Issue 4, pp 615–620

A study of glycogen storage disease with 99Tcm-MIBI gated myocardial perfusion imaging

  • L. G. Wei
  • J. Q. Gao
  • X. M. Liu
  • J. M. Huang
  • X. Z. Li
Original Article



Gated myocardial perfusion imaging (G-MPI) is regularly performed using single-photon emission computed tomography. The objective of this study was to evaluate the clinical value of 99Tcm-methoxyisobutylisonitrile (MIBI) myocardial imaging in glycogen storage disease (GSD).


99Tcm-MIBI G-MPI was performed in nine patients with clinically proven GSD. QGS quantitative software was used for processing and interpretation. Left ventricular ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic volume (ESV) were automatically generated. The myocardium was divided into seven segments, 20 sub-segments and a five-point scoring system was used.


Seven out of nine cases were abnormal and the positive rate of G-MPI was 77.8 %. Sixty-two sub-segments of injured myocardium were detected in 140 sub-segments of seven abnormal patients. One injured segment was observed in one patient (14.3 %), two segments were detected in two patients (28.6 %) and three or more abnormal segments were observed in four patients (57.1 %).


99Tcm-MIBI G-MPI can detect myocardial damage in GSD as a non-invasive method. It plays an important role in the clinic.


Glycogen storage disease Tomography Emission computed Single-photon MIBI 


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Copyright information

© Royal Academy of Medicine in Ireland 2013

Authors and Affiliations

  • L. G. Wei
    • 1
  • J. Q. Gao
    • 1
  • X. M. Liu
    • 1
  • J. M. Huang
    • 1
  • X. Z. Li
    • 1
  1. 1.Department of Nuclear MedicineThe Third Affiliated Hospital of Hebei Medical UniversityShijiazhuangChina

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