Atomoxetine-induced life-threatening long QT syndrome
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Attention deficit hyperactivity disorder (ADHD) is a developmental disorder with symptoms that may overlap and combine with those of learning disabilities, oppositional defiant disorder, and emotional problems, often due to post-traumatic stress following abuse . The physiology of ADHD is an imbalance in catecholamine metabolism in the cerebral cortex, with inhibitory dopaminergic and noradrenergic activities decreased .
ADHD is treated with medication acting through dopaminergic and noradrenergic pathways, which are commonly stimulants. An alternative is atomoxetine (ATM), a selective norepinephrine reuptake inhibitor.
There are few reports of cardiovascular adverse effects of ATM. Due to the rare reports of serious cardiac events, ATM was labeled with cardiac risk warnings, but only when administered in excess of therapeutic doses, having generally no effect on cardiac repolarization, as measured by the QTc interval [3, 4]. ATM was not associated with a clinically significant...
KeywordsAttention Deficit Hyperactivity Disorder Methylphenidate Attention Deficit Hyperactivity Disorder Zolpidem Atomoxetine
Conflict of interests
The authors have no personal affiliations, financial relationship or any commercial interest to disclose relative to this article. The submitted report or any essential part of it is not published or simultaneously submitted to other publications prior to its appearance in this Journal.
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