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Irish Journal of Medical Science

, Volume 182, Issue 3, pp 509–511 | Cite as

Through the looking glass; bioactive glass S53P4 (BonAlive®) in the treatment of chronic osteomyelitis

  • J. McAndrewEmail author
  • C. Efrimescu
  • E. Sheehan
  • D. Niall
Brief Report

Abstract

Background

In terms of eradication, osteomyelitis represents one of the most challenging infective conditions in medicine and surgery. In recent years, the use of bioactive glass in conjunction with antimicrobial therapy has emerged as a viable new treatment.

Aim

We present a short study, from a regional orthopaedic unit, demonstrating its successful use in three patients with chronic osteomyelitis.

Methods

Between September 2010 and May 2011, bioactive glass S53P4 was used in conjunction with intravenous and oral antibiotics to treat chronic osteomyelitis in three patients (two male, one female). All patients underwent debridement and sequestrectomy procedures with the insertion of bioactive glass followed by antimicrobial regimens tailored to isolated pathogen sensitivities. Patient age ranged from 28 to 68 years, with a mean age of 44.7 years. The presentation period, from time of initial diagnosis to treatment, varied from 16 months to 16 years and all three patients had underwent multiple previous debridements and antimicrobial regimens to no avail.

Results

A follow-up of 14–21 months has been achieved with a mean follow-up of 17.3 months. We have seen excellent results in all three patients. All haematological and biochemical parameters have returned to normal, pain has ceased and function has returned in the affected limbs. All antibiotics have stopped and there is no radiological evidence of osteomyelitis. The bioactive glass has integrated with the surrounding bone.

Conclusions

Though a relatively recent development, bioactive glass used in concurrence with antibiotic therapy has significant potential in the treatment of chronic osteomyelitis.

Keywords

PMMA Osteomyelitis Bioactive Glass Amorphous Calcium Phosphate Chronic Osteomyelitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Lindfors NC et al (2010) Bioactive glass S53P4 as bone graft substitute in treatment of osteomyelitis. Bone 47:212–218PubMedCrossRefGoogle Scholar
  2. 2.
    Paluska SA (2004) Osteomyelitis. Clin Family Prac 6:127–156CrossRefGoogle Scholar
  3. 3.
    Konttinen YT et al (2001) Acid attack and cathepsin K in bone resorption around total hip replacement prosthesis. J Bone Miner Res 16:1780–1786PubMedCrossRefGoogle Scholar
  4. 4.
    Geurts J et al (2011) Bone graft substitutes in active or suspected infection. Contra-indicated or not? Injury 42:S82–S86PubMedCrossRefGoogle Scholar
  5. 5.
    Hench LL et al (1971) Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res 5(6):117–141CrossRefGoogle Scholar
  6. 6.
    Rahaman MN et al (2011) Bioactive glass in tissue engineering. Acta Biomater 7:2355–2373PubMedCrossRefGoogle Scholar
  7. 7.
    Stoor P et al (1999) Interactions between the bioactive glass S53P4 and the atrophic rhinitis-associated microorganism Klebsiella ozaenae. J Biomed Mater Res 48:869–874PubMedCrossRefGoogle Scholar

Copyright information

© Royal Academy of Medicine in Ireland 2013

Authors and Affiliations

  • J. McAndrew
    • 1
    Email author
  • C. Efrimescu
    • 1
  • E. Sheehan
    • 1
  • D. Niall
    • 1
  1. 1.Department of Orthopaedic SurgeryMidland Regional HospitalTullamoreIreland

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