Outcome of pregnancy in type 1 diabetes mellitus (T1DMP): results from combined diabetes–obstetrical clinics in Dublin in three university teaching hospitals (1995–2006)
To compare the pregnancy outcomes in all T1DMP attending at combined (diabetes–obstetric) outpatients clinics in three university teaching hospitals in Dublin from 1995 to 2006 with a non-diabetic control population (C) attending at antenatal outpatient clinics at the same hospitals over the same period.
T1DMP (n = 600) were compared with control non-diabetic pregnancies (n = 142,498).
The spontaneous abortion rate was 15% in T1DMP versus 8% in C (p < 0.0001). Perinatal mortality rate was 3.3% in T1DMP compared to 0.9% in C (p < 0.001). The incidence of foetal macrosomia was 29% in T1DMP versus 16% in C (p < 0.001).
Pregnancy outcomes in T1DMP remain worse than in the general population despite management of T1DMP in combined obstetric/diabetes clinics in a single centre using similar management protocols. These outcomes in our study population of T1DMP in Dublin appear better than some previously reported studies.
KeywordsT1DM Pregnancy Outcomes Macrosomia Perinatal mortality Combined diabetes/obstetrical clinic
I am grateful to the diabetes nurse specialists, midwives, medical records staff and obstetricians at the various maternity hospitals comprising the Dublin Diabetes Pregnancy Centre, who made this work possible.
Conflict of interest
None of the authors have any conflicts of interest to declare.
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