Irish Journal of Medical Science

, Volume 180, Issue 1, pp 255–257 | Cite as

Anti-glycolipid GM2-positive Guillain–Barre syndrome due to hepatitis E infection

  • S. Cronin
  • R. McNicholas
  • E. Kavanagh
  • V. Reid
  • K. O’Rourke
Brief Report



Hepatitis E infection is most prevalent in developing countries with poor sanitation, but can also occur apparently sporadically in more developed areas.


We here report a second European case of Guillain–Barre syndrome due to hepatitis E infection in association with anti-glycolipid GM2 antibody.


This is likely to be a specific association involving molecular mimicry, and further European cases can therefore be expected.


Guillain–Barre syndrome Anti-glycoprotein antibodies Hepatitis E 


  1. 1.
    Aggarwal R, Naik S (2009) Epidemiology of hepatitis E: current status. J Gastroenterol Hepatol 24:1484–1493CrossRefPubMedGoogle Scholar
  2. 2.
    Loly JP, Rikir E, Seivert M et al (2009) Guillain–Barre syndrome following hepatitis E. World J Gastroenterol 15:1645–1647CrossRefPubMedGoogle Scholar
  3. 3.
    Sood A, Midha V, Sood N (2000) Guillain–Barre syndrome with acute hepatitis E. Am J Gastroenterol 95:3667–3668PubMedGoogle Scholar
  4. 4.
    Kamani P, Baijal R, Amarapurkar D et al (2005) Guillain–Barre syndrome associated with acute hepatitis E. Indian J Gastroenterol 24:216PubMedGoogle Scholar
  5. 5.
    Kumar R, Bhoi S, Kumar M et al (2002) Guillain–Barre syndrome and acute hepatitis E: a rare association. J Indian Acad Clin Med 3:389–391Google Scholar
  6. 6.
    Ono S, Chida K, Takasu T (1994) Guillain–Barre syndrome following fulminant viral hepatitis A. Intern Med 33:799–801CrossRefPubMedGoogle Scholar
  7. 7.
    Tsukada N, Koh C, Inoue A et al (1987) Demyelinating neuropathy associated with hepatitis B virus infection. J Neurol Sci 77:203–216CrossRefPubMedGoogle Scholar
  8. 8.
    Klippel N, Hautekeete M, Keyser J et al (1993) Guillain–Barre syndrome as the presenting manifestation of hepatitis C infection. Neurology 43:2143PubMedGoogle Scholar
  9. 9.
    Lin S, Ryu S, Liaw Y (1989) Guillain–Barre syndrome associated with acute delta hepatitis virus superinfection. J Med Virol 28:144–145CrossRefPubMedGoogle Scholar
  10. 10.
    Yadav K, Rohatgi A, Sharma S et al (2002) Oculomotor palsy associated with hepatitis E infection. J Assoc Physicians India 50:731Google Scholar
  11. 11.
    Kejariwal D, Roy S, Sarkar N (2001) Seizure associated with acute hepatitis E. Neurology 57:1935PubMedGoogle Scholar
  12. 12.
    Mandal K, Chopra N (2006) Acute transverse myelitis following hepatitis E virus infection. Indian Pediatr 43:365–366PubMedGoogle Scholar
  13. 13.
    Fong F, Illahi M (2009) Neuralgia amyotrophy associated with hepatitis E virus. Clin Neurol Neurosurg 111:193–195CrossRefPubMedGoogle Scholar
  14. 14.
    Kamar N, Izopet J, Cintas P et al (2010) Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis. Am J Transplant 10:1321–1324CrossRefPubMedGoogle Scholar
  15. 15.
    Dalton H, Bendall R, Ijaz S et al (2008) Hepatitis E: an emerging infection in developed countries. Lancet Infect Dis 8:698–709CrossRefPubMedGoogle Scholar
  16. 16.
    Hughes R, Cornblath D (2005) Guillain–Barre syndrome. Lancet 366:1653–1656CrossRefPubMedGoogle Scholar
  17. 17.
    Carpo M, Pedotti R, Allaria S et al (1999) Clinical presentation and outcome of Guillain–Barre and related syndromes in relation to anti-ganglioside antibodies. J Neurol Sci 168:178–184CrossRefGoogle Scholar
  18. 18.
    Hartnung HP, Kieseier R (1999) Antibody responses in the Guillain–Barre syndrome. J Neurol Sci 168:75–77CrossRefGoogle Scholar
  19. 19.
    Sheikh K, Ho T, Nachamkin I et al (1998) Molecular mimicry in Guillain–Barre syndrome. Ann N Y Acad Sci 845:307–321CrossRefPubMedGoogle Scholar

Copyright information

© Royal Academy of Medicine in Ireland 2010

Authors and Affiliations

  • S. Cronin
    • 1
  • R. McNicholas
    • 1
  • E. Kavanagh
    • 2
  • V. Reid
    • 3
  • K. O’Rourke
    • 1
  1. 1.Dublin Neurological InstituteMater Misericordiae University HospitalDublin 7Ireland
  2. 2.Department of RadiologyMater Misericordiae University HospitalDublinIreland
  3. 3.Department of NeurophysiologyMater Misericordiae University HospitalDublinIreland

Personalised recommendations