Irish Journal of Medical Science

, Volume 180, Issue 2, pp 319–325 | Cite as

Effects of exercise and physical activity on depression

  • P. C. DinasEmail author
  • Y. Koutedakis
  • A. D. Flouris
Review Article



Depression is a very prevalent mental disorder affecting 340 million people globally and is projected to become the leading cause of disability and the second leading contributor to the global burden of disease by the year 2020.


In this paper, we review the evidence published to date in order to determine whether exercise and physical activity can be used as therapeutic means for acute and chronic depression. Topics covered include the definition, classification criteria and treatment of depression, the link between β-endorphin and exercise, the efficacy of exercise and physical activity as treatments for depression, properties of exercise stimuli used in intervention programs, as well as the efficacy of exercise and physical activity for treating depression in diseased individuals.


The presented evidence suggests that exercise and physical activity have beneficial effects on depression symptoms that are comparable to those of antidepressant treatments.


Exercise Depression Physical activity Mood β-Endorphin 



This work was supported in part by funding from the European Union 7th Framework Program (FP7-PEOPLE-IRG-2008 grant no. 239521).


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Copyright information

© Royal Academy of Medicine in Ireland 2010

Authors and Affiliations

  1. 1.Department of Sport and Exercise ScienceUniversity of ThessalyTrikalaGreece
  2. 2.FAME Laboratory, Institute of Human Performance and RehabilitationCentre for Research and TechnologyThessalyGreece
  3. 3.Department of Research and Technology DevelopmentBiomnic Ltd.TrikalaGreece

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