Motility of the ureter of the spontaneously hypertensive rat
- 79 Downloads
The spontaneously hypertensive rat (SHR) is a commonly used animal model of hypertension and transplantation studies provide evidence for a renal element to the aetiology of the hypertensive process.
This study was designed to test the hypothesis that the contractile function of the ureter of the SHR differs to that of the normotensive control Wistar–Kyoto (WKY) rat.
Ureter segments from SHR (n = 16) and WKY (n = 16) were cannulated and pressurised in vitro. Acetylcholine (ACh) was used to stimulate phasic contractile pressure responses.
SHR ureter contractile frequencies were significantly greater than those of WKY (6.6 ± 0.8 vs. 3.8 ± 0.2 min−1 in 10−5 M ACh; p < 0.01). Magnitudes of contractile responses were not significantly different (SHR 14.3 ± 1.5 mmHg, WKY 15.2 ± 2.1 mmHg).
SHR ureteral contractile function differs significantly to that of normotensive WKY. Ureteral dysfunction may be a contributory causative factor in the aetiology of the hypertensive disease process.
KeywordsUreter Urothelium Acetylcholine Smooth muscle Nitric oxide Hypertension Spontaneously hypertensive rat
This work was funded by the UCD Seed Funding Scheme and the UCD School of Medicine and Medical Science.
- 10.Ofstad J, Iversen BM (2005) Glomerular and tubular damage in normotensive and hypertensive rats. Am J Physiol 288:F665–F672Google Scholar
- 17.Rasidovich D, Bund SJ (2008) Regional differences in rat ureter contractile responses assessed by a novel in vitro approach. Irish J Med Sci 177(Suppl II):S364Google Scholar