Irish Journal of Medical Science

, Volume 179, Issue 4, pp 623–627

Prevalence and clinical significance of 15 autoantibodies in patients with new-onset systemic lupus erythematosus

  • W.-X. Li
  • H.-F. Pan
  • L.-H. Li
  • N. Zhang
  • J. Li
  • Y.-G. Fan
  • J.-B. Feng
  • X.-W. Tang
  • H. Chen
  • X.-P. Li
  • D.-Q. Ye
Brief Report

Abstract

Introduction

It is necessary to assay multiple autoantibodies simultaneously in the same group of new-onset systemic lupus erythematosus (SLE) patient.

Aim

To determine the prevalence and clinical significance of 15 autoantibodies in patients with new-onset SLE.

Methods

Twenty new-onset patients with SLE and 32 healthy individuals were enrolled in the present study. Serum levels of 15 autoantibodies were detected by enzyme linked immunosorbent assay. The clinical parameters of the patients were also recorded.

Results

The positive rate of anti-ssDNA was the highest (85%). The positive rates of anti-dsDNA, anti-ssDNA, AHA, anti-SSA, anti-SSB, anti-Sm, anti-U1RNP, AnuA, and rRNP were significantly higher in SLE patients than in nomal controls. In terms of clinical manifestation, there were significant associations of rRNP with photaesthesia and of AHA with nephritis.

Conclusion

Clusters of autoantibodies were identified and associations of antibodies with symptoms were found in new-onset patients with SLE.

Keywords

Autoantibodies Diagnosis Systemic lupus erythematosus 

References

  1. 1.
    Sherer Y, Gorstein A, Fritzler MJ et al (2004) Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients. Semin Arthritis Rheum 34:501–537CrossRefPubMedGoogle Scholar
  2. 2.
    Fernandez SA, Lobo AZ, Oliveira ZN et al (2003) Prevalence of antinuclear autoantiodies in the serum of normal blood donors. Rev Hosp Clin Fac Med Sao Paulo 58:315–319PubMedGoogle Scholar
  3. 3.
    Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725CrossRefPubMedGoogle Scholar
  4. 4.
    Pan HF, Fang XH, Wu GC et al (2008) Anti-neutrophil cytoplasmic antibodies in new-onset systemic lupus erythematosus and lupus nephritis. Inflammation 31:260–265CrossRefPubMedGoogle Scholar
  5. 5.
    Kurien BT, Scofield RH (2006) Autoantibody determination in the diagnosis of systemic lupus erythematosus. Scand J Immunol 64:227–235CrossRefPubMedGoogle Scholar
  6. 6.
    Arbuckle MR, McClain MT, Rubertone MV et al (2003) Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 349:1526–1533CrossRefPubMedGoogle Scholar
  7. 7.
    Zandman-Goddard G, Gilburd B, Shovman O et al (2005) The homogeneous multiplexed system—a new method for autoantibody profile in systemic lupus erythematosus. Clin Dev Immunol 12:107–111CrossRefPubMedGoogle Scholar
  8. 8.
    Ravirajan CT, Rowse L, MacGowan JR et al (2001) An analysis of clinical disease activity and nephritis-associated serum autoantibody profiles in patients with systemic lupus erythematosus: a cross-sectional study. Rheumatology 40:1405–1412CrossRefPubMedGoogle Scholar
  9. 9.
    Isenberg DA, Ravirajan CT, Rahman A et al (1997) The role of antibodies to DNA in systemic lupus erythematosus—a review and introduction to an international workshop on DNA antibodies held in London, May 1996. Lupus 6:290–304CrossRefPubMedGoogle Scholar
  10. 10.
    Beaufils M, Kouki F, Mignon F et al (1983) Clinical significance of anti-Sm antibodies in systemic lupus erythematosus. Am J Med 74:201–205CrossRefPubMedGoogle Scholar
  11. 11.
    Berden JH, Licht R, van Bmggen MC et al (1999) Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis. Curr Opin Nephrol Hypertens 8:299–306CrossRefPubMedGoogle Scholar
  12. 12.
    Yalaoui S, Gorgi Y, Hajri R et al (2002) Autoantibodies to ribosomal P proteins in systemic lupus erythematosus. Joint Bone Spine 69:173–176CrossRefPubMedGoogle Scholar
  13. 13.
    Yee CS, Hussein H, Skan J et al (2003) Association of damage with autoantibody profile, age, race, sex and disease duration in systemic lupus erythematosus. Rheumatology (Oxford) 42:276–279CrossRefGoogle Scholar

Copyright information

© Royal Academy of Medicine in Ireland 2010

Authors and Affiliations

  • W.-X. Li
    • 1
  • H.-F. Pan
    • 1
  • L.-H. Li
    • 1
  • N. Zhang
    • 1
  • J. Li
    • 1
  • Y.-G. Fan
    • 1
  • J.-B. Feng
    • 1
  • X.-W. Tang
    • 1
  • H. Chen
    • 1
  • X.-P. Li
    • 2
  • D.-Q. Ye
    • 1
  1. 1.Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical UniversityHefeiChina
  2. 2.Department of RheumatologyAnhui Provincial HospitalHefeiChina

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