Primary cardiac lymphoma: diagnostic tools and treatment challenges
Primary cardiac lymphoma (PCL) is a rare malignancy and the optimal treatment strategy remains uncertain. It appears to respond much better to systemic chemotherapy than to surgery and it should be considered in the differential diagnosis of all cardiac tumours before definitive management is undertaken. We report a case of this rare disorder treated successfully with a combination of rituximab and cyclophosphamide, adriamycin, vincristine and prednisolone. The patient developed recurrent unstable ventricular tachycardia (VT) post-chemotherapy secondary to extensive scarring at the tumour site. The tumour as well as the post-treatment scarring is well illustrated by cardiac magnetic resonance imaging highlighting its usefulness in this setting. An implantable cardioverter defibrillator (ICD) was placed. This is only the second case in the literature of PCL to have an ICD placed for recurrent VT. A brief literature review is included.
KeywordsPrimary cardiac lymphoma Cardiac tumours Non-Hodgkins lymphoma
Conflict of interest statement
- 1.Burke A, Virmani R (1996) Tumours of the heart and great vessels. In: Rosai J, Sobin LH (eds) Atlas of tumour pathology, 3rd Series, Fasicle 16. Armed Forces Institute of Pathology, Washington DC, pp 171–179Google Scholar
- 4.Miyashita T, Miyazawa I, Kawaguchi T, Kasai T, Yamaura T (2000) A case of primary cardiac B cell lymphoma associated with ventricular tachycardia, successfully treated with systemic chemotherapy and radiotherapy: a long-term survival case. Jpn Circ J 64(2):135–138. doi: 10.1253/jcj.64.135 CrossRefPubMedGoogle Scholar