Irish Journal of Medical Science

, Volume 181, Issue 3, pp 353–355 | Cite as

Acromegaly associated with gangliocytoma

  • R. K. Crowley
  • Y. al-Derazi
  • K. Lynch
  • D. Rawluk
  • C. J. Thompson
  • M. Farrell
  • A. Agha
Case Report



Acromegaly secondary to growth hormone-releasing hormone (GHRH) excess is rare.

Aims/case description

We report two patients with acromegaly who were diagnosed with sellar gangliocytomas that were immunopositive for GHRH. Tumour tissue persisted after debulking surgery and in the second case this was associated with persistent growth hormone hypersecretion, successfully suppressed by a somatostatin analogue.


The development of functional pituitary adenomas in association with sellar gangliocytomas is poorly understood. We present a brief discussion of the possible aetiology of these unusual pituitary tumours.


Acromegaly Gangliocytoma Growth hormone-releasing hormone 



Dr Rachel Crowley is the beneficiary of an unrestricted educational grant from Novo Nordisk.


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Copyright information

© Royal Academy of Medicine in Ireland 2009

Authors and Affiliations

  • R. K. Crowley
    • 1
  • Y. al-Derazi
    • 2
  • K. Lynch
    • 2
  • D. Rawluk
    • 3
  • C. J. Thompson
    • 1
  • M. Farrell
    • 2
  • A. Agha
    • 1
  1. 1.Academic Department of EndocrinologyBeaumont HospitalDublin 9Ireland
  2. 2.Department of NeuropathologyBeaumont HospitalDublin 9Ireland
  3. 3.Department of NeurosurgeryBeaumont HospitalDublin 9Ireland

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