Advertisement

Irish Journal of Medical Science

, Volume 176, Issue 2, pp 87–90 | Cite as

Changing patterns of thyroid carcinoma

  • B. Dijkstra
  • R. S. Prichard
  • A. Lee
  • L. M. Kelly
  • P. P. A. Smyth
  • T. Crotty
  • E. W. McDermott
  • A. D. K. Hill
  • N. O’Higgins
Original Article

Abstract

Background

To assess changing trends in histological types of thyroid cancer in an Irish hospital over the past 30 years.

Methods

Biographical data, tumour characteristics, treatment and outcome from 190 patients with thyroid carcinoma from 1970 to 2000 were reviewed retrospectively.

Results

Detailed records of 190 patients with thyroid cancer were identified with a mean age at presentation of 50 years. From 1970 to 1979 the distribution of histological types was: papillary carcinoma; 9 patients (4.7%), follicular; 17 patients (8.9%), anaplastic; 9 patients (4.7%), medullary; 1 patient (0.5%) and lymphoma; 1 patient (0.5%). From 1980 to 1989 papillary carcinoma accounted for 32 patients (16.8%), follicular; 14 patients (7.3%), anaplastic; 13 patients (6.8%), medullary; 7 patients (3.7%) and lymphoma; 5 patients (2.6%). From 1990 to 1999 papillary cancer accounted for 48 patients (25.2%), follicular; 14 patients (7.3%), anaplastic; 8 patients (4.2%), medullary; 7 patients (3.7%) and lymphoma; 5 patients (2.6%). Survival rates were significantly better for those aged less than 45 years (P < 0.0001), female sex (P < 0.01) and those with papillary carcinoma (P < 0.01).

Conclusions

This study demonstrated a significant increase in the incidence of papillary carcinoma. This may be related to increasing dietary iodine intake and may be significant as papillary carcinoma is associated with a more favourable prognosis.

Keywords

Epidemiology Iodine uptake Prognosis Thyroid carcinoma Thyroid surgery 

References

  1. 1.
    Pettersson B, Adami HO, Wilander E, Coleman MP (1991) Trends in thyroid cancer incidence in Sweden, 1958–1981, by histopathological type. Int J Cancer 48(1):28–33PubMedCrossRefGoogle Scholar
  2. 2.
    Mulla ZD, Margo CE (2000) Primary malignancies of the thyroid epidemiological analysis of the Florida cancer data system registry. Ann Epidemiol 10(1):24–30PubMedCrossRefGoogle Scholar
  3. 3.
    Fahey TJ, Reeve TS, Delbridge L (1995) Increasing incidence and changing presentation of thyroid cancer over a 30-year period. Br J Surg 82:518–520PubMedCrossRefGoogle Scholar
  4. 4.
    Lawal O, Agbakwuru A, Olayinka OS, Adelusola K (2001) Thyroid malignancy in endemic nodular goitres: prevalence, pattern and treatment. Eur J Surg Oncol 27:157–161PubMedCrossRefGoogle Scholar
  5. 5.
    Clark OH, Duh Q. (1991) Thyroid cancer. Med Clin North Am 75:211–234PubMedGoogle Scholar
  6. 6.
    Hay ID, Grant CS, Taylor WF, McConahey WM (1987) Ipsilateral lobectomy versus bilateral lobar resection in papillary thyroid carcinoma: a retrospective analysis of surgical outcome using a novel prognostic scoring system. Surgery 102:1088–1095PubMedGoogle Scholar
  7. 7.
    Sebastian SO, Gonzalez JM, Paricio P et al (2000) Papillary thyroid carcinoma. Arch Surg 135:272–277PubMedCrossRefGoogle Scholar
  8. 8.
    Finn SP, Smyth P, O’Leary J, Sweeney EC, Sheils O (2003) Ret/PTC chimeric transcripts in an Irish cohort of sporadic papillary thyroid carcinoma. J Clin Endocrinol Metab 88(2):938–941PubMedCrossRefGoogle Scholar
  9. 9.
    Galloway JW, Sardi A, DeConti RW, Mitchell WT, Bolton JS (1991) Changing trends in thyroid surgery. 38 years experience. Am Surg 57(1):18–20PubMedGoogle Scholar
  10. 10.
    Feldt-Rasmussen U (2001) Iodine and cancer. Thyroid 11(5):483–488PubMedCrossRefGoogle Scholar
  11. 11.
    Burgess JR, Dwyer T, McArdle K, Tucker P, Shugg D (2000) The changing incidence and spectrum of thyroid carcinoma in Tasmania (1978–1998) during a transition from iodine sufficiency to iodine deficiency. J Clin Endocrinol Metab 85(4):1513–1517PubMedCrossRefGoogle Scholar
  12. 12.
    Smyth PPA, Hetherton AM, O’Carroll D et al (1988) Iodine intake in Ireland—an update. Ir J Med Sci 157(12):377–379PubMedGoogle Scholar
  13. 13.
    Hetherton AM, McKenna TJ, Counihan TB, Poole DBR, O’Donovan DK, O’Higgins NJ, Smyth PPA (1989) Seasonal variations in iodine intake in Ireland. Ir J Med Sci 159:127Google Scholar
  14. 14.
    Smyth PPA, Smith DF, Radcliff M, O’Herlihy C (1997) Maternal iodine status and thyroid volume during pregnancy: correlation with neonatal intake. J Clin Endocrinol Met 82:2840–2843CrossRefGoogle Scholar
  15. 15.
    Fortner JC, George PA, Sternberg SS (1960) Induced and spontaneous thyroid cancer in the Syrian (golden) hamster. Endocrinology 66:364–376CrossRefGoogle Scholar
  16. 16.
    Kim JY, Kim KR (2000) Dietary iodine intake and urinary iodine excretion in patients with thyroid diseases. Yonsei Med J 41(1):22–28PubMedGoogle Scholar
  17. 17.
    Lind P, Langsteger W, Molnar M et al (1998) Epidemiology of thyroid diseases in iodine sufficiency. Thyroid 8(12):1179–1183PubMedCrossRefGoogle Scholar
  18. 18.
    Jonasson JG, Hrafnkelsson J, Bjornsson J (1989) Tumours in Iceland. Malignant tumours of the thyroid gland. A histological classification and epidemiological considerations. APMIS 97(7):625–630PubMedCrossRefGoogle Scholar
  19. 19.
    Goodman MT, Yoshizawa CN, Kolonel LN (1988) Descriptive epidemiology of thyroid cancer in Hawaii. Cancer 61:1272–1281PubMedCrossRefGoogle Scholar
  20. 20.
    Tzavara I, Vlassopoulou B, Alevizaki C et al (1999) Differentiated thyroid cancer: a retrospective analysis of 832 cases from Greece. Clin Endocrinol 50:643–654CrossRefGoogle Scholar
  21. 21.
    Schneider AB, Shore-Freeman E, Weinstein RA (1986) Radiation induced thyroid and other head and neck tumours: occurrence of multiple tumours and analysis of risk factors. J Clin Endocrinol Metab 63:107–115PubMedGoogle Scholar
  22. 22.
    Jacob P, Kenigsberg Y, Goulko G et al (2000) Thyroid cancer risk in Belarus after the Chernobyl accident: comparison with external exposures. Radiat Environ Biophys 39:25–31PubMedCrossRefGoogle Scholar
  23. 23.
    Hamilton TE, van Belle G, LoGerfo JP (1987) Thyroid neoplasia in Marshall Islanders exposed to nuclear fallout. JAMA 238:629–34CrossRefGoogle Scholar
  24. 24.
    Shaw JHF, Dodds P (1990) Carcinoma of the thyroid gland in Auckland, New Zealand. Surg Gynecol Obstet 171:27–32PubMedGoogle Scholar
  25. 25.
    Learoyd DL, Messina M, Zedenius J, Robinson BG (2000) Molecular genetics of thyroid tumours and surgical decision-making. World J Surg 24:923–33PubMedCrossRefGoogle Scholar

Copyright information

© Royal Academy of Medicine in Ireland 2007

Authors and Affiliations

  • B. Dijkstra
    • 1
  • R. S. Prichard
    • 1
  • A. Lee
    • 1
  • L. M. Kelly
    • 1
  • P. P. A. Smyth
    • 2
  • T. Crotty
    • 3
  • E. W. McDermott
    • 1
  • A. D. K. Hill
    • 1
  • N. O’Higgins
    • 1
  1. 1.Department of SurgerySt Vincent’s University HospitalDublin 4Ireland
  2. 2.Endocrine LaboratoryUniversity College DublinDublinIreland
  3. 3.Department of PathologySt Vincent’s University HospitalDublinIreland

Personalised recommendations