, Volume 67, Issue 11, pp 2534–2542 | Cite as

New Bismuth-Substituted Hydroxyapatite Nanoparticles for Bone Tissue Engineering

  • Gabriela Ciobanu
  • Ana Maria Bargan
  • Constantin Luca


New bismuth-substituted hydroxyapatite [Ca10−x Bi x (PO4)6(OH)2 where x = 0–2.5] nanoparticles were synthesized by the co-precipitation method from aqueous solutions. The structural properties of the samples were analyzed by scanning electron microscopy coupled with x-ray analysis, x-ray powder diffraction, x-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and Brunauer–Emmett–Teller surface area analysis. The results confirm that bismuth ions have been incorporated into the hydroxyapatite lattice. The prepared nanocrystalline powders consisted of hydroxyapatite as single phase with hexagonal structure, crystal sizes smaller than 60 nm and (Bi + Ca)/P atomic ratio of around 1.67. The hydroxyapatite samples doped with Bi have mesoporous textures with pores size of around 2 nm and specific surface area in the range of 12–25 m2/g. The Bi-substituted hydroxyapatite powders are more effective against Gram-negative Escherichia coli bacteria than Gram-positive Staphylococcus aureus bacteria.


Bismuth Hydroxyapatite Hydroxyapatite Powder Apatite Lattice Pure Hydroxyapatite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© The Minerals, Metals & Materials Society 2015

Authors and Affiliations

  • Gabriela Ciobanu
    • 1
  • Ana Maria Bargan
    • 1
  • Constantin Luca
    • 1
  1. 1.Faculty of Chemical Engineering and Environmental Protection“Gheorghe Asachi” Technical University of IasiIasiRomania

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