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JOM

, Volume 66, Issue 4, pp 573–579 | Cite as

Immunological Response to Biodegradable Magnesium Implants

  • Karin PichlerEmail author
  • Stefan Fischerauer
  • Peter Ferlic
  • Elisabeth Martinelli
  • Hans-Peter Brezinsek
  • Peter J. Uggowitzer
  • Jörg F. Löffler
  • Annelie-Martina Weinberg
Article

Abstract

The use of biodegradable magnesium implants in pediatric trauma surgery would render surgical interventions for implant removal after tissue healing unnecessary, thereby preventing stress to the children and reducing therapy costs. In this study, we report on the immunological response to biodegradable magnesium implants—as an important aspect in evaluating biocompatibility—tested in a growing rat model. The focus of this study was to investigate the response of the innate immune system to either fast or slow degrading magnesium pins, which were implanted into the femoral bones of 5-week-old rats. The main alloying element of the fast-degrading alloy (ZX50) was Zn, while it was Y in the slow-degrading implant (WZ21). Our results demonstrate that degrading magnesium implants beneficially influence the immune system, especially in the first postoperative weeks but also during tissue healing and early bone remodeling. However, rodents with WZ21 pins showed a slightly decreased phagocytic ability during bone remodeling when the degradation rate reached its maximum. This may be due to the high release rate of the rare earth-element yttrium, which is potentially toxic. From our results we conclude that magnesium implants have a beneficial effect on the innate immune system but that there are some concerns regarding the use of yttrium-alloyed magnesium implants, especially in pediatric patients.

Keywords

Magnesium Alloy Innate Immune System Elastic Stable Intramedullary Nail Phagocytic Ability Biodegradable Implant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The authors acknowledge support from the Laura Bassi Center of Expertise BRIC (Bioresorbable Implants for Children; FFG—Austria). The authors would also like to thank Ms. Katharina Angerpointer (Department of Pediatric Surgery, Medical University of Graz, Austria) and Ms. Verena Krischnan for their help with collection and workup of the blood specimens.

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Copyright information

© The Minerals, Metals & Materials Society 2014

Authors and Affiliations

  • Karin Pichler
    • 1
    Email author
  • Stefan Fischerauer
    • 1
  • Peter Ferlic
    • 2
  • Elisabeth Martinelli
    • 1
  • Hans-Peter Brezinsek
    • 3
  • Peter J. Uggowitzer
    • 4
  • Jörg F. Löffler
    • 4
  • Annelie-Martina Weinberg
    • 1
  1. 1.Department of Orthopaedic SurgeryMedical University of GrazGrazAustria
  2. 2.Department of Orthopaedic SurgeryMedical University of InnsbruckInnsbruckAustria
  3. 3.Department of Rheumatology and ImmunologyMedical University of GrazGrazAustria
  4. 4.Laboratory of Metal Physics and Technology, Department of MaterialsZurichSwitzerland

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