, Volume 63, Issue 4, pp 93–98

Calcium phosphate ceramics in drug delivery

  • Susmita Bose
  • Solaiman Tarafder
  • Joe Edgington
  • Amit Bandyopadhyay
Biomaterials for Regenerative Medicine Overview


Calcium phosphate (CaP) particulates, cements and scaffolds have attracted significant interest as drug delivery vehicles. CaP systems, including both hydroxyapaptite and tricalcium phosphates, possess variable stoichiometry, functionality and dissolution properties which make them suitable for cellular delivery. Their chemical similarity to bone and thus biocompatibility, as well as variable surface charge density contribute to their controlled release properties. Among specific research areas, nanoparticle size, morphology, surface area due to porosity, and chemistry controlled release kinetics are the most active. This article discusses CaP systems in their particulate, cements, and scaffold forms for drug, protein, and growth factor delivery toward orthopedic and dental applications.


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Copyright information

© TMS 2011

Authors and Affiliations

  • Susmita Bose
    • 1
  • Solaiman Tarafder
    • 1
  • Joe Edgington
    • 1
  • Amit Bandyopadhyay
    • 1
  1. 1.W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials EngineeringWashington State UniversityPullmanUSA

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