Bio tribune magazine

, Volume 36, Issue 1, pp 30–35

Détermination de HER2 dans les adénocarcinomes pour établir le pronostic et prédire la réponse aux traitements

  • P. Maroun
  • J. Gligorov
  • J. Ohnona
  • C. Murariu
  • Y. Belkacémi
Mise au Point

Résumé

Les avancées enregis trées depuis la caractérisation des cibles jusqu’à l’utilisation des thérapies ciblées sont un modèle de développement de l’innovation en cancérologie. La surexpression de HER2 est considérée de façon très hétérogène selon le type de cancer au plan du pronostic et pour prédire la réponse à une thérapie ciblée. Dans le cancer du sein, la surexpression de HER2 a d’abord été considérée comme un facteur pronostique avant de révolutionner la stratégie thérapeutique de 20 % des patients. Dans les autres localisations, de nombreuses publications rappor tent un intérêt pronostique de HER2, avec cependant un impact moindre en termes de prédiction de réponse au trastuzumab que dans le cancer du sein.

Mots clés

HER2 cancer pronostic prédiction de réponse trastuzumab 

Impact of HER2 status to define prognosis and to predict treatment efficacy in adenocarcinomas

Abstract

The significant advances registered from targets definition to the use of targeted therapies are a model of innovative development in Oncology. HER2 overexpression has first been reported as progno stic factor before its consideration as a main parameter to predict treatment efficacy. In breast cancer HER2 determination is considered as a revolution for therapeutic strategy of about 15 to 20% of the patients. On the other hand, while HER2 is considered as a prognostic factor for many other cancers, its ability to predict efficacy of trastuzumab is much lower than in breast cancer.

Keywords

HER2 cancer prognostic prediction of response Trastuzumab 

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Copyright information

© Springer Verlag France 2010

Authors and Affiliations

  • P. Maroun
    • 1
    • 2
  • J. Gligorov
    • 3
  • J. Ohnona
    • 1
    • 2
  • C. Murariu
    • 1
    • 2
  • Y. Belkacémi
    • 1
    • 2
  1. 1.Service d’oncologie-radiothérapiehôpital Henri-Mondor, AP-HPCréteilFrance
  2. 2.Faculté de médecine de Créteiluniversité de Parix-XIICréteil cedexFrance
  3. 3.ervice d’oncologie médicale, hôpital Tenon, AP-HP, Cancer-Estuniversité de Paris-VIParisFrance

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