Review of Patient-Specific Vascular Modeling: Template-Based Isogeometric Framework and the Case for CAD

  • Benjamin Urick
  • Travis M. Sanders
  • Shaolie S. HossainEmail author
  • Yongjie J. Zhang
  • Thomas J. R. Hughes
Original Paper


We review the literature on patient-specific vascular modeling, with particular attention paid to three-dimensional arterial networks. Patient-specific vascular modeling typically involves three main steps: image processing, analysis suitable model generation, and computational analysis. Analysis suitable model generation techniques that are currently utilized suffer from several difficulties and complications, which often necessitate manual intervention and crude approximations. Because the modeling pipeline spans multiple disciplines, the benefits of integrating a computer-aided design (CAD) component for the geometric modeling tasks has been largely overlooked. Upon completion of our review, we adopt this philosophy and present a CAD-integrated template-based modeling framework that streamlines the construction of solid non-uniform rational B-spline vascular models for performing isogeometric finite element analysis. Examples of arterial models for mouse and human circles of Willis and a porcine coronary tree are presented.



Support from the William Stamps Farish Fund, Portuguese CoLab grant no UTA06-894, and William & Ella Owens Medical Research Foundation grant no UTA17-000357 are gratefully acknowledged. The authors would also like to thank Zbigniew Starosolski and Ananth Annapragada at the Texas Children’s Hospital, Raja Muthupillai at St. Luke’s Hospital, and Andrea Gobin and Doris Taylor at Texas Heart Institute for providing the imaging data, and for their help with image processing.

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


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Copyright information

© CIMNE, Barcelona, Spain 2017

Authors and Affiliations

  1. 1.Institute for Computational Engineering and SciencesThe University of Texas at AustinAustinUSA
  2. 2.Department of Molecular CardiologyTexas Heart InstituteHoustonUSA
  3. 3.Department of Mechanical EngineeringCarnegie Mellon UniversityPittsburghUSA

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