Korean Journal of Chemical Engineering

, Volume 36, Issue 1, pp 166–172 | Cite as

pH-triggered intracellular release of doxorubicin from polyaspartamide-encapsulated mesoporous silica nanoparticles

  • Cheolwon Lim
  • Eun-Bum Cho
  • Dukjoon KimEmail author
Polymer, Industrial Chemistry


Mesoporous silica nanoparticles (MSNs) conjugating doxorubicin (DOX) via a pH-sensitive cleavable linkage, hydrazine (HYD) were synthesized. MSN-HYD-DOX were encapsulated with the polyaspartamide (PASPAM) grafted with the hydrophilic o-(2-aminoethyl)-o′-methylpoly(ethylene glycol) (PEG) and the cell permeating ligand, biotin (Biotin). The chemical structure of the synthesized MSN-HYD-DOX and PASPAM-g-PEG/Biotin was confirmed using FT-IR and 1H-NMR spectroscopy. The mean diameter of the MSN-HYD-DOX@PASPAM-g-PEG/Biotin nanoparticle was 142 nm and 121 nm, respectively, examined by dynamic light scattering (DLS) and transmission electron microscope (TEM). The HYD bond was effectively cleaved in acidic condition, and thus DOX was released much faster at pH 5.0 than at pH 7.4. The cell viability in MSN-HYD-DOX@PASPAM-g-PEG/Biotin system was much lower than that of the free DOX drug because of efficient intracellular drug delivery associated with the biotin ligand.


Mesoporous Silica Nanoparticle Polysuccinimide Hydrazone Bond Doxorubicin 


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© Korean Institute of Chemical Engineers, Seoul, Korea 2019

Authors and Affiliations

  1. 1.School of Chemical EngineeringSungkyunkwan UniversitySuwon, GyeonggiKorea
  2. 2.Department of Fine ChemistrySeoul National University of Science and TechnologySeoulKorea

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