Korean Journal of Chemical Engineering

, Volume 33, Issue 11, pp 3175–3183 | Cite as

Kinetics and thermodynamics of paclitaxel extraction from plant cell culture

  • Tae Wan Kim
  • Jin-Hyun KimEmail author


We investigated the effect of temperature on the efficiency of paclitaxel extraction from biomass. In addition, kinetic and thermodynamic studies of this extraction process were performed. The concentration of extracted paclitaxel increased with increasing extraction temperature and extraction time. When the experimental data were applied to various kinetic models, the hyperbolic model (second-order model) was the most appropriate. The predictive model was developed to predict the concentration of extracted paclitaxel at different temperatures at a given time. The Gibbs free energy change was determined to be negative, while enthalpy change and entropy change were positive. These results indicate that this extraction process is spontaneous, endothermic, and irreversible.


Paclitaxel Extraction Kinetics Predictive Model Thermodynamics 


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Copyright information

© Korean Institute of Chemical Engineers, Seoul, Korea 2016

Authors and Affiliations

  1. 1.Department of Chemical EngineeringKongju National UniversityCheonanKorea

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