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Korean Journal of Chemical Engineering

, Volume 31, Issue 6, pp 1028–1035 | Cite as

Synthesis, recognition and evaluation of molecularly imprinted polymer nanoparticle using miniemulsion polymerization for controlled release and analysis of risperidone in human plasma samples

  • Ebadullah Asadi
  • Saman Azodi-Deilami
  • Majid Abdouss
  • Davood Kordestani
  • Alireza Rahimi
  • Somayeh Asadi
Biotechnology

Abstract

We prepared high selective imprinted nanoparticle polymers by a miniemulsion polymerization technique, using risperidone as the template, MAA as the functional monomers, and TRIM as the cross-linker in acetonitrile as solvent. The morphology of the nanoparticles determined by scanning electron microscopy (SEM) images and drug release, binding properties and dynamic light scattering (DLS) of molecularly imprinted polymers (MIPs) were studied. Controlled release of risperidone from nanoparticles was investigated through in 1% wt sodium dodecyl sulfate aqueous solution and by measuring the absorbance by HPLC-UV. The results showed that the imprinted nanoparticles exhibited a higher binding level and slower release rate than non-imprinted nanoparticles, which contributed to interaction of risperidone with imprinted cavities within nanoparticles. Furthermore, the results from HPLC showed good precision (5% for 50.0 μg L−1) and recoveries (between 86–91) using MIP from human plasma samples.

Keywords

Molecularly Imprinted Polymers Risperidone Sustained Release Human Plasma Miniemulsion Polymerization 

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Copyright information

© Korean Institute of Chemical Engineers, Seoul, Korea 2014

Authors and Affiliations

  • Ebadullah Asadi
    • 1
  • Saman Azodi-Deilami
    • 1
  • Majid Abdouss
    • 1
  • Davood Kordestani
    • 2
  • Alireza Rahimi
    • 3
  • Somayeh Asadi
    • 4
  1. 1.Department of ChemistryAmirkabir University of TechnologyTehranIran
  2. 2.Faculty of Chemistry, Department of Organic ChemistryRazi UniversityKermanshahIran
  3. 3.Electrochemistry and Inhibitors Group, Environmental Protection DepartmentResearch Institute of Petroleum Industry (RIPI)TehranIran
  4. 4.Student research committeeKermanshah University of Medical SciencesKermanshahIran

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