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Korean Journal of Chemical Engineering

, Volume 30, Issue 7, pp 1359–1367 | Cite as

Viruses as self-assembled nanocontainers for encapsulation of functional cargoes

  • Yuanzheng Wu
  • Hetong Yang
  • Hyun-Jae Shin
Review Paper

Abstract

Viruses naturally exhibit an incredible variety of sophisticated nanostructures, which makes them ideal biological building blocks for nanoengineered material research. By mimicking their spontaneous assembly process, tremendous advances have been made towards utilizing virus and virus-like particles (VLPs) as protein cages, scaffolds, and templates for nanomaterials in the last few years. This review outlines recent progress in the field of bionanotechnology in which viruses are introduced to encapsulate various functional cargoes in a precise and controlled fashion. The encapsulation mechanisms are summarized into three main strategies: electrostatic interaction, chemical conjugation, and covalent attachment by genetic manipulation. The combination with chemical modification and genetic engineering heralds a brilliant future for fabrication of functional nanomaterials. These well-defined architectures will find attractive applications in biosensing, drug delivery, enzyme confinement, light-harvesting system, and pharmaceutical therapy.

Key words

Virus Virus-like Particles (VLPs) Encapsulation Nanomaterials Drug Delivery 

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Copyright information

© Korean Institute of Chemical Engineers, Seoul, Korea 2013

Authors and Affiliations

  1. 1.Department of Chemical and Biochemical EngineeringChosun UniversityGwangjuKorea
  2. 2.Biotechnology Center of Shandong Academy of SciencesJinanChina

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