Smart delivery system for cosmetic ingredients using pH-sensitive polymer hydrogel particles

  • Eunmi Lee
  • Bumsang KimEmail author
Transport Phenomena Rapid Communication


pH-Sensitive P(MAA-co-EGMA) hydrogel microparticles were prepared and their feasibility as smart delivery carriers for cosmetically active ingredients such as arbutin, adenosine, and niacinamide was evaluated. P(MAAco-EGMA) hydrogel microparticles were synthesized via dispersion photopolymerization. There was a drastic change in the swelling ratio of P(MAA-co-EGMA) microparticles at a pH of around 5. The loading efficiency of the cosmetic ingredients was affected by the electrostatic interaction between the hydrogel and the cosmetic ingredients. The P(MAAco-EGMA) hydrogel microparticles showed a pH-sensitive release behavior. Thus, at pH 4 almost none of the cosmetic ingredients except adenosine permeated through the skin, while at pH 6 relatively high skin permeability was obtained. These results indicate that the P(MAA-co-EGMA) hydrogel microparticles synthesized in this study have the potential to be used as a smart carrier for cosmetic ingredients triggered by an external pH change for cosmetic applications.

Key words

Hydrogel Microparticles Cosmetic Ingredients Arbutin Adenosine Niacinamide pH-sensitive Smart Delivery System Skin Permeability 


  1. 1.
    J. R. Kaczvinsky and P. E. Grimes, J. Drugs Dermatol., 8, S15 (2009).Google Scholar
  2. 2.
    D. L. Bissett, Clin. Dermatol., 27, 435 (2009).CrossRefGoogle Scholar
  3. 3.
    Z. D. Draelos, Clin. Dermatol, 27, 431 (2009).CrossRefGoogle Scholar
  4. 4.
    M. P. Lupo, Clin. Dermatol., 19, 467 (2001).CrossRefGoogle Scholar
  5. 5.
    S. Farahmand, H. Tajerzadeh and E. S. Farboud, Pharm. Dev. Technol., 11, 255 (2006).CrossRefGoogle Scholar
  6. 6.
    A. Kogan and N. Garti, Adv. Colloid Interf., 123, 369 (2006).CrossRefGoogle Scholar
  7. 7.
    S. Lee and B. Jin, Appl. Chem., 8, 13 (2004).Google Scholar
  8. 8.
    Z. Drulis-Kawa and A. Dorotkiewicz-Jach, Int. J. Pharmaceut., 387, 187 (2010).CrossRefGoogle Scholar
  9. 9.
    F. Agnely, A. Djedour, A. Bochot and J. L. Grossiord, J. Drug Deliv. Sci. Tec., 16, 3 (2006).Google Scholar
  10. 10.
    D. Kim, Y. Jeong, C. Choi, S. Roh, S. Kang, M. Jang and J. Nah, Int. J. Pharmaceut., 319, 130 (2006).CrossRefGoogle Scholar
  11. 11.
    M. Oh, J. Lee, S. Kim, S Kim, K. Park, H. Yun, K. Baek, N. Kwon and D. Kim, J. Soc. Cosmet. Scientists Korea, 35, 19 (2009).Google Scholar
  12. 12.
    J. Y. Legendre, I. Schnitzler, Q. Li, C. Hausen, M. Huart, G. S. Luengo, M. L. Abella and M. Roreger, J. Cosmet. Sci., 58, 147 (2007).Google Scholar
  13. 13.
    O. Sorg, C. Antille, G. Kaya and H. H. Saurat, Dermatol. Ther., 19, 289 (2006).CrossRefGoogle Scholar
  14. 14.
    C. Park, M. Shin and H. Kim, Korean J. Chem. Eng., 25, 581 (2008).CrossRefGoogle Scholar
  15. 15.
    E. Hong, D. T. M. Nguyen, D. H. Nguyen and E. Kim, Korean J. Chem. Eng., 25, 1463 (2008).CrossRefGoogle Scholar
  16. 16.
    D. L. Bissett, K. Miyamoto, P. Sun, J. Li and C. A. Berge, Int. J. Cosmet. Sci., 26, 231 (2004).CrossRefGoogle Scholar
  17. 17.
    C. Lin, H. Wu and Y. Huang, Anal. Chim. Acta, 581, 102 (2007).CrossRefGoogle Scholar

Copyright information

© Korean Institute of Chemical Engineers, Seoul, Korea 2011

Authors and Affiliations

  1. 1.Department of Chemical EngineeringHongik UniversitySeoulKorea

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