Wiener klinische Wochenschrift Education

, Volume 5, Issue 1, pp 31–47

Systemischer Lupus Erythematodes (SLE)

Original Article


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Hunnangkul S, Nitsch D, Rhodes B, Chadha S, Roberton CA, Pessoa-Lopes P, et al (2008) Familial clustering of non-nuclear autoantibodies and C3 and C4 complement components in systemic lupus erythematosus. Arthritis Rheum 58: 1116–1124CrossRefPubMedGoogle Scholar
  2. Crispin JC, Liossis SN, Kis-Toth K, Lieberman LA, Kyttaris VC, Juang YT, et al (2010) Pathogenesis of human systemic lupus erythematosus: recent advances. Trends Mol Med 16: 47–57CrossRefPubMedGoogle Scholar
  3. Hahn BH, Ebling F, Singh RR, Singh RP, Karpouzas G, La Cava A (2005) Cellular and molecular mechanisms of regulation of autoantibody production in lupus. Ann N Y Acad Sci 1051: 433–441CrossRefPubMedGoogle Scholar
  4. Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA, et al (2003) Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 349: 1526–1533CrossRefPubMedGoogle Scholar
  5. Munoz LE, Janko C, Grossmayer GE, Frey B, Voll RE, Kern P, et al (2009) Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus. Arthritis Rheum 60: 1733–1742CrossRefPubMedGoogle Scholar
  6. Wallace DJ, Stohl W, Furie RA, Lisse JR, McKay JD, Merrill JT, et al (2009) A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus. Arthritis Rheum 61: 1168–1178CrossRefPubMedGoogle Scholar
  7. Bonelli M, Smolen JS, Scheinecker C (2010) Treg and lupus. Ann Rheum Dis 69 [Suppl 1]: i65–66CrossRefPubMedGoogle Scholar
  8. Klinman DM, Steinberg AD (1995) Inquiry into murine and human lupus. Immunol Rev 144: 157–193CrossRefPubMedGoogle Scholar
  9. Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, et al (2005) Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 175: 8392–8400PubMedGoogle Scholar
  10. Toussirot E, Roudier J (2008) Epstein-Barr virus in autoimmune diseases. Best Pract Res Clin Rheumatol 22: 883–896CrossRefPubMedGoogle Scholar
  11. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25: 1271–1277CrossRefPubMedGoogle Scholar
  12. McKinley PS, Ouellette SC, Winkel GH (1995) The contributions of disease activity, sleep patterns, and depression to fatigue in systemic lupus erythematosus. A proposed model. Arthritis Rheum 38: 826–834CrossRefPubMedGoogle Scholar
  13. Santiago MB, Galvao V (2008) Jaccoud arthropathy in systemic lupus erythematosus: analysis of clinical characteristics and review of the literature. Medicine (Baltimore) 87: 37–44CrossRefGoogle Scholar
  14. Weening JJ, D'Agati VD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, et al (2004) The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol 15: 241–250CrossRefPubMedGoogle Scholar
  15. The Canadian Hydroxychloroquine Study Group (1991) A randomized study of the effect of withdrawing hydroxychloroquine sulfate in systemic lupus erythematosus. N Engl J Med 324: 150–154CrossRefGoogle Scholar
  16. Jung H, Bobba R, Su J, Shariati-Sarabi Z, Gladman DD, Urowitz M, et al (2010) The protective effect of antimalarial drugs on thrombovascular events in systemic lupus erythematosus. Arthritis Rheum 62: 863–868CrossRefPubMedGoogle Scholar
  17. Wilson K, Abeles M (1994) A 2 year, open ended trial of methotrexate in systemic lupus erythematosus. J Rheumatol 21: 1674–1677PubMedGoogle Scholar
  18. Tam LS, Li EK, Wong CK, Lam CW, Li WC, Szeto CC (2006) Safety and efficacy of leflunomide in the treatment of lupus nephritis refractory or intolerant to traditional immunosuppressive therapy: an open label trial. Ann Rheum Dis 65: 417–418CrossRefPubMedGoogle Scholar
  19. Grossman JM (2009) Lupus arthritis. Best Pract Res Clin Rheumatol 23: 495–506CrossRefPubMedGoogle Scholar
  20. Barile L, Lavalle C (1992) Transverse myelitis in systemic lupus erythematosus – the effect of IV pulse methylprednisolone and cyclophosphamide. J Rheumatol 19: 370–372PubMedGoogle Scholar
  21. Houssiau FA, Vasconcelos C, D'Cruz D, Sebastiani GD, Garrido Ed Ede R, Danieli MG, et al (2002) Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum 46: 2121–2131CrossRefPubMedGoogle Scholar
  22. Contreras G, Pardo V, Leclercq B, Lenz O, Tozman E, O'Nan P, et al (2004) Sequential therapies for proliferative lupus nephritis. N Engl J Med 350: 971–980CrossRefPubMedGoogle Scholar
  23. Looney RJ, Anolik J, Sanz I (2010) A perspective on B-cell-targeting therapy for SLE. Mod Rheumatol 20: 1–10CrossRefPubMedGoogle Scholar
  24. Looney RJ (2010) B cell-targeted therapies for systemic lupus erythematosus: an update on clinical trial data. Drugs 70: 529–540CrossRefPubMedGoogle Scholar
  25. Illei GG, Shirota Y, Yarboro CH, Daruwalla J, Tackey E, Takada K, et al (2010) Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study. Arthritis Rheum 62: 542–552CrossRefPubMedGoogle Scholar
  26. Merrill JT, Burgos-Vargas R, Westhovens R, Chalmers A, D'Cruz D, Wallace DJ, Bae SC, Sigal LH, Becker JC, Kelly S, et al (2009) Activity of Abatacept in SLE: Results of a 12-month phase II exploratory study. Annual European Congress of Rheumatology (EULAR), 2009Google Scholar
  27. Aringer M, Steiner G, Graninger WB, Höfler E, Steiner CW, Smolen JS, et al (2007) Effects of short-term infliximab therapy on autoantibodies in systemic lupus erythematosus. Arthritis Rheum 56: 274–279CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Klinische Abteilung für RheumatologieUniversitätsklinik für Innere Medizin IIIMedizinische Universität WienAustria

Personalised recommendations