Clinical Oncology and Cancer Research

, Volume 6, Issue 4, pp 277–281 | Cite as

Clinicopathologic observation of 6 cases with neuroendocrine carcinoma of the urinary bladder

  • Shufang Shi
  • Shuyuan Chen
  • Xiaoge Zhou
  • Shoufang Huang



To discuss the pathologic characteristics and the prognosis of neuroendocrine carcinoma of the bladder (NECB) in order to assist in making a precise diagnosis and to effectively treat the disease.


Clinicopathologic features of the 6 cases with NECB were analyzed retrospectively. The personal data of the patients and the pathologic and immunohistochemical characteristics of the tumor were investigated. The follow-up of these patients was conducted over a time period ranging from 3 months to 9 years.


Transurethral resection of the bladder tumor was performed in all 6 patients. Based on the results of the pathologic examination, 4 of the cases were diagnosed as small cell neuroendocrine carcinoma and the other 2 were diagnosed as atypical carcinoid tumor. On immunohistochemical staining all tumors expressed neuroendocrine markers including neuronspecific enolase (CD56), synaptophysin (Syn) and chromogranin (CgA). In patients receiving partial cystectomy followed by postoperative chemotherapy, relapse was found in 4 of the 6 cases on follow up.


NECB is a rare entity and a tumor with high malignant potential and characteristic pathologic features. Hematuria is the cardinal symptom of NECB. Metastasis may occur at an early stage and the prognosis of the disease is poor. Final diagnosis of NECB depends on histopathologic examination and immunohistochemical assays. Surgical excision combined with radiotherapy and chemotherapy is considered an effective treatment.

Key Words

bladder neoplasms carcinoma neuroendocrine pathologic diagnosis 


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  1. 1.
    Ganim RB, Norton JA. Recent advances in carcinoid pathogenesis, diagnosis and management. Surg Oncol 2000; 9: 173–179.PubMedCrossRefGoogle Scholar
  2. 2.
    Yu JQ, Yang GS, Shi SF. Primary carcinoid tumor of the urinary bladder (report of 4 cases). Zhonghua Miniao Waike Zazhi 2003; 24: 836–838 (Chinese).Google Scholar
  3. 3.
    Ali SZ, Reuter VE, Zakowski MF. Small cell neuroendocrine carcinoma of the urinary bladder. A clinicopathologic study with emphasis on cytologic features. Cancer 1997; 79: 356–361.PubMedCrossRefGoogle Scholar
  4. 4.
    Blomjous CE, Vos W, De Voogt HJ, et al. Small cell carcinoma of the urinary bladder. A clinicopathologic, morphometric, immunohistochemical, and ultrastructural study of 18 cases. Cancer 1989; 64: 1347–1357.PubMedCrossRefGoogle Scholar
  5. 5.
    Grignon DJ, Ro JY, Ayala AG, et al. Small cell carcinoma of the urinary bladder:a clinicopathologic analysis of 22 cases. Cancer 1992; 69: 527–536.PubMedCrossRefGoogle Scholar
  6. 6.
    Walker BF, Someren A, Kennedy JC, et al. Primary carcinoid tumor of the urinary bladder. Arch Pathol Lab Med 1992; 116: 1217–1220.PubMedGoogle Scholar
  7. 7.
    Martignool G, Eble JN. Carcinoid tumors of the urinary bladder: immunohisto-chemical study of 2 cases and review of the literature. Arch Pathol Lab Med 2003; 127: 22–24.Google Scholar
  8. 8.
    Lu XY, Xiao D. Small cell neuroendocrine combined carcinoma of the urinary bladder: a case report and literature review. Linchuang Yu Shiyan Binglixue Zazhi 1999; 15: 124–126 (Chinese).Google Scholar
  9. 9.
    Frese R, Doehn C, Baumgartel M, et al. Carcinoid tumor in an ileal neobladder. Urol 2001; 165: 522–523.CrossRefGoogle Scholar
  10. 10.
    Lester JF, Hudson JB, Barber JB. Bladder preservation in small cell carcinoma of the urinary bladder: an institutional experience and review of the literature. Clin Oncol 2006; 18: 608–611.CrossRefGoogle Scholar
  11. 11.
    Song Y, Xi ZJ, Kong XT, et al. Small cell carcinoma of the bladder: a report of 5 cases. Zhonghua Miniao Waike Zazhi 2001; 22: 214–216 (Chinese).Google Scholar

Copyright information

© Tianjin Medical University Cancer Institute and Hospital and Springer Berlin Heidelberg 2009

Authors and Affiliations

  • Shufang Shi
    • 1
  • Shuyuan Chen
    • 1
  • Xiaoge Zhou
    • 1
  • Shoufang Huang
    • 1
  1. 1.Department of Pathology, Beijing Friendship HospitalAffiliated to Capital University of Medical SciencesBeijingChina

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