Clinical Oncology and Cancer Research

, Volume 6, Issue 2, pp 104–112

Synergistic action of clonorchiasis, HBV infection and alcohol consumption on primary hepatocellular carcinoma

  • Shengkui Tan
  • Xiaoqiang Qiu
  • Hongping Yu
  • Xiaoyun Zeng
  • Zengming Xiao
  • Lequn Li
  • Qiuan Zhong
Article

DOI: 10.1007/s11805-009-0104-0

Cite this article as:
Tan, S., Qiu, X., Yu, H. et al. Clin. Oncol. Cancer Res. (2009) 6: 104. doi:10.1007/s11805-009-0104-0
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Abstract

Objective

It has been recognized that HBV infection and alcohol consumption are two important risk factors for primary hepatocellular carcinoma (HCC). Recently, the role of clonorchiasis as a risk factor for HCC is controversial. We aimed to investigate whether these factors increase the risk of HCC in Guangxi, China.

Methods

A hospital-based, case-control study of HCC was conducted from July 2005 to July 2007. We enrolled 500 consecutive patients with HCC as an experimental group and 500 patients without tumor in liver as a control group. The risk factors that the patients were exposed to were assessed.

Results

Comparing the risks of developing the HCC, we found out the following results. The risk of developing HCC for the patients with clonorchiasis was 5 folds of that for the patients without clonorchiasis (OR = 5.0; 95% CI: 3.1–8.1), and the risk for the patients with alcohol consumption was 3 folds of that for the patients without drinking alcohol (OR = 3.4; 95% CI: 2.3–4.9), and similarly, the risk for the patients with HBV infection was 21 times of that for the patients without HBV infection (OR = 20.6; 95% CI: 14.3–29.7). According to crossover analysis, there was significant interaction among clonorchiasis, HBV infection and alcohol consumption, with synergistic indices greater than 1. The etiologic fractions attributed to these interactions [EF (A × B)] are 0.7465, 0.5789 and 0.5506, respectively.

Conclusion

Clonorchiasis, HBV infection and heavy alcohol consumption are independent risk factors for developing HCC in our population in Guangxi, and as they can interact synergistically, the risk of developing HCC is increased. Data from this study may indicate new prevention strategies of developing HCC in high-risk individuals.

Key Words

primary hepatocellular carcinoma risk factor clonorchiasis HBV infection alcohol consumption synergistic action 

Copyright information

© Tianjin Medical University Cancer Institute and Hospital and Springer-Verlag GmbH 2009

Authors and Affiliations

  • Shengkui Tan
    • 1
  • Xiaoqiang Qiu
    • 1
  • Hongping Yu
    • 2
  • Xiaoyun Zeng
    • 2
  • Zengming Xiao
    • 3
  • Lequn Li
    • 3
  • Qiuan Zhong
    • 2
  1. 1.Department of Preventative MedicineGuilin Medical CollegeGuilinChina
  2. 2.Department of Epidemiology, School of Public HealthGuangxi Medical UniversityNanningChina
  3. 3.Department of Hepatobiliary SurgeryThe First Hospital of Guangxi Medical UniversityNanningChina

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