Chinese Journal of Clinical Oncology

, Volume 3, Issue 3, pp 191–195 | Cite as

MDR1/P-glycoprotein overexpression in bladder transitional cell carcinoma and its correlation with expression of survivin and Fas

  • Changli Wu
  • Wenlan Zhang
  • Jiwu Chang
  • Zuohui Zhao
  • Guang Sun
  • Ruifa Han
Original Articles

Abstract

OBJECTIVE To explore the expression of the MDR1/P-glycoprotein, Fas and survivin and to examine their correlation with the biologic behavior of bladder transitional cell carcinoma (BTCC).

METHODS Immunohistochemistry was used to examine the expression of P-gp, survivin and Fas in BTCC (n=64) and normal bladder mucosa (n=12).

RESULTS The expression level of P-gp and survivin in BTCC was higher compared to normal bladder mucosa (P<0.01) and their expression was strongly correlated with clinical grading (P<0.01). In BTCC and normal bladder mucosa Fas expression was 50% and 100%, respectively (P<0.01). Recurrent BTCC showed higher expression than primary BTCC (P<0.01) and the expression of P-gp in BTCC had a reverse correlation with Fas expression but no correlation with survivin expression.

CONCLUSUON The MDR of BTCC was strongly correlated with the expression of P-gp and Fas, but was not correlated with survivin expression. Thus, enhancing cancer sensitivity to chemotherapy by reversing multidrug resistance with reversal agents or up-regulating Fas expression by apoptotic enhancing agents, might be a potential therapy to prevent tumor recurrence and invasiveness.

Keywords

bladder transitional cell carcinoma P-glycoprotein multidrug resistance survivin Fas 

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Copyright information

© Chinese Anti-Cancer Association and Springer 2003

Authors and Affiliations

  • Changli Wu
    • 1
  • Wenlan Zhang
    • 1
  • Jiwu Chang
    • 1
  • Zuohui Zhao
    • 1
  • Guang Sun
    • 1
  • Ruifa Han
    • 1
  1. 1.Tianjin Urological DepartmentTianjin Institute of Urologic Surgery, the Second Hospital of Tianjin Medical UniversityTianjinChina

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