Journal of Ocean University of China

, Volume 17, Issue 4, pp 967–972 | Cite as

Synthesis and Neuroprotective Activity of Neolamellarin A Analogues

  • Meng Zhang
  • Ruijuan Yin
  • Yiran Zhang
  • Cui Hao
  • Lijuan ZhangEmail author
  • Tao JiangEmail author


Alkaloids are a class of natural products with a wide range of biological activities. Due to the special living environment, the alkaloids from marine sponges have exhibited different biological activities and promising medical application potential. Neolamellarin A is a marine alkaloid possessing bisaryl-pyrrole structural features. Here, the synthesis of 12 different 3,4-bisaryl-N-alkylated permethylated analogues of neolamellarin A and their outstanding neuroprotective activity in PC12 cells are presented and discussed.

Key words

alkaloids neolamellarin A synthesis PC12 cells neuroprotective activity 


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This study is supported by the National Natural Science Foundation of China (Nos. 21171154 and 81672585), the Key Technology Fund of Shandong Province (No. 2016ZDJS07 A07), and the Taishan Scholar Fellowship of Shandong Province in China to L. Z.


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Copyright information

© Science Press, Ocean University of China and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Systems Biology and Medicine Center for Complex DiseasesAffiliated Hospital of Qingdao UniversityQingdaoChina
  2. 2.School of Medicine and PharmacyOcean University of ChinaQingdaoChina
  3. 3.Marine Biomedical Research Institute of QingdaoQingdaoChina

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