Journal of Ocean University of China

, Volume 11, Issue 2, pp 205–212

Properties of polysaccharides in several seaweeds from Atlantic Canada and their potential anti-influenza viral activities

  • Guangling Jiao
  • Guangli Yu
  • Wei Wang
  • Xiaoliang Zhao
  • Junzeng Zhang
  • Stephen H. Ewart
Doctor Forum

DOI: 10.1007/s11802-012-1906-x

Cite this article as:
Jiao, G., Yu, G., Wang, W. et al. J. Ocean Univ. China (2012) 11: 205. doi:10.1007/s11802-012-1906-x

Abstract

To explore the polysaccharides from selected seaweeds of Atlantic Canada and to evaluate their potential anti-influenza virus activities, polysaccharides were isolated from several Atlantic Canadian seaweeds, including three red algae (Polysiphonia lanosa, Furcellaria lumbricalis, and Palmaria palmata), two brown algae (Ascophyllum nodosum and Fucus vesiculosus), and one green alga (Ulva lactuca) by sequential extraction with cold water, hot water, and alkali solutions. These polysaccharides were analyzed for monosaccharide composition and other general chemical properties, and they were evaluated for anti-influenza virus activities. Total sugar contents in these polysaccharides ranged from 15.4% (in U. lactuca) to 91.4% (in F. lumbricalis); sulfation level was as high as 17.6% in a polysaccharide from U. lactuca, whereas it could not be detected in an alikali-extract from P. palmaria. For polysaccharides from red seaweeds, the main sugar units were sulfated galactans (agar or carrageenan) for P. lanosa, F. lumbricalis, and xylans for P. palmata. In brown seaweeds, the polysaccharides largely contained sulfated fucans, whereas the polysaccharides in green seaweed were mainly composed of heteroglycuronans. Screening for antiviral activity against influenza A/PR/8/34 (H1N1) virus revealed that brown algal polysaccharides were particularly effective. Seaweeds from Atlantic Canada are a good source of marine polysaccharides with potential antiviral properties.

Key words

polysaccharides anti-influenza viral activity monosaccharide composition H1N1 

Copyright information

© Science Press, Ocean University of China and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Guangling Jiao
    • 1
    • 2
    • 3
  • Guangli Yu
    • 1
    • 2
  • Wei Wang
    • 4
  • Xiaoliang Zhao
    • 1
    • 2
  • Junzeng Zhang
    • 5
  • Stephen H. Ewart
    • 3
  1. 1.Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and PharmacyOcean University of ChinaQingdaoP. R. China
  2. 2.Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, School of Medicine and PharmacyOcean University of ChinaQingdaoP. R. China
  3. 3.National Research Council Canada-Institute for Marine BiosciencesHalifaxCanada
  4. 4.Laboratory of Molecular Pharmacology, School of Medicine and PharmacyOcean University of ChinaQingdaoP. R. China
  5. 5.National Research Council Canada-Institute for Nutrisciences and HealthCharlottetownCanada
  6. 6.Novaceutics ConsultingHalifaxCanada

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