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PPCPs in a drinking water treatment plant in the Yangtze River Delta of China: Occurrence, removal and risk assessment

  • Xinshu Jiang
  • Yingxi Qu
  • Liquan Liu
  • Yuan He
  • Wenchao Li
  • Jun HuangEmail author
  • Hongwei Yang
  • Gang Yu
Research Article
  • 16 Downloads

Abstract

The occurrence and removal of 39 targeted pharmaceuticals and personal care products (PPCPs) from source water, through a drinking water treatment plant (DWTP) to the water supply station, were investigated around the central part of Yangtze River Delta in China using both grab sampling and continuous sampling. Totally 24 of the 39 targeted PPCPs were detected in raw water, and 12 PPCPs were detected in the finished water. The highest observed concentration was enrofloxacin (85.623 ng/L) in raw water. Removal efficiencies were remarkably negative correlated with log Kow (r = - 0.777, p<0.01) after calibration control of concentration, indicating that more soluble PPCPs are easier to remove by the combined process (prechlorination and flocculation/precipitation), the concentration level also had a great impact on the removal efficiency. The normal process in the pilot DWTP seems to be ineffective for PPCPs control, with the limited removal efficiency of less than 30% for each step: pre-chlorination, flocculation and precipitation, post-chlorination and filter. There were notable differences between the data from continuous sampling and grab sampling, which should be considered for different monitoring purposes. The chlorination and the hydrolytic decomposition of PPCPs in the water supply pipe may attenuate PPCPs concentration in the pipeline network. The PPCPs examined in the effluent of DWTP do not impose a potential health risk to the local consumers due to their RQ value lower than 0.00067.

Keywords

PPCPs DWTP Human health risk assessment 

Notes

Acknowledgements

This research was financially supported by the Major Science and Technology Program for Water Pollution Control and Treatment in China under Grant (Nos. 2017ZX07202001 and 2017ZX07202004).

Supplementary material

11783_2019_1109_MOESM1_ESM.pdf
Supplementary material, approximately 228 KB.

References

  1. Aristizabal-Ciro C, Botero-Coy A M, López F J, Peñuela G A (2017). Monitoring pharmaceuticals and personal care products in reservoir water used for drinking water supply. Environmental Science and Pollution Research International, 24(8): 7335–7347Google Scholar
  2. Azzouz A, Ballesteros E (2013). Influence of seasonal climate differences on the pharmaceutical, hormone and personal care product removal efficiency of a drinking water treatment plant. Chemosphere, 93(9): 2046–2054Google Scholar
  3. Boleda M A, Galceran M A, Ventura F (2011). Behavior of pharmaceuticals and drugs of abuse in a drinking water treatment plant (DWTP) using combined conventional and ultrafiltration and reverse osmosis (UF/RO) treatments. Environmental Pollution, 159(6): 1584–1591Google Scholar
  4. Bu Q, Wang B, Huang J, Deng S, Yu G (2013). Pharmaceuticals and personal care products in the aquatic environment in China: A review. Journal of Hazardous Materials, 262: 189–211Google Scholar
  5. Buerge I J, Kahle M, Buser H R, Müller M D, Poiger T (2008). Nicotine derivatives in wastewater and surface waters: Application as chemical markers for domestic wastewater. Environmental Science & Technology, 42(17): 6354–6360Google Scholar
  6. Caban M, Lis E, Kumirska J, Stepnowski P (2015). Determination of pharmaceutical residues in drinking water in Poland using a new SPE-GC-MS(SIM) method based on Speedisk extraction disks and DIMETRIS derivatization. Science of the Total Environment, 538: 402–411Google Scholar
  7. Cai M Q, Wang R, Feng L, Zhang L Q (2015). Determination of selected pharmaceuticals in tap water and drinking water treatment plant by high-performance liquid chromatography-triple quadrupole mass spectrometer in Beijing, China. Environmental Science and Pollution Research International, 22(3): 1854–1867Google Scholar
  8. Carmona E, Andreu V, Picó Y (2014). Occurrence of acidic pharmaceuticals and personal care products in Turia River Basin: From waste to drinking water. Science of the Total Environment, 484: 53–63Google Scholar
  9. Chang X, MeyerMT, Liu X, Zhao Q, Chen H, Chen J A, Qiu Z, Yang L, Cao J, Shu W (2010). Determination of antibiotics in sewage from hospitals, nursery and slaughter house, wastewater treatment plant and source water in Chongqing region of Three Gorge Reservoir in China. Environmental Pollution, 158(5): 1444–1450Google Scholar
  10. Dai G,Wang B, Huang J, Dong R, Deng S, Yu G (2015). Occurrence and source apportionment of pharmaceuticals and personal care products in the Beiyun River of Beijing, China. Chemosphere, 119: 1033–1039Google Scholar
  11. de Jesus Gaffney V, Almeida C M M, Rodrigues A, Ferreira E, Benoliel M J, Cardoso V V (2015). Occurrence of pharmaceuticals in a water supply system and related human health risk assessment. Water Research, 72: 199–208Google Scholar
  12. de Jongh C M, Kooij P J F, de Voogt P, ter Laak T L (2012). Screening and human health risk assessment of pharmaceuticals and their transformation products in Dutch surface waters and drinking water. Science of the Total Environment, 427-428: 70–77Google Scholar
  13. de Voogt P, Janex-Habibi M L, Sacher F, Puijker L, Mons M (2009). Development of a common priority list of pharmaceuticals relevant for the water cycle. Water Science and Technology, 59(1): 39–46Google Scholar
  14. Diwan V, Stålsby Lundborg C, Tamhankar A J (2013). Seasonal and temporal variation in release of antibiotics in hospital wastewater: Estimation using continuous and grab sampling. PLoS One, 8(7): 1–7Google Scholar
  15. Dodd M C, Huang C H (2004). Transformation of the antibacterial agent sulfamethoxazole in reactions with chlorine: Kinetics, mechanisms, and pathways. Environmental Science & Technology, 38(21): 5607–5615Google Scholar
  16. Emmerson A M, Jones A M (2003). The quinolones: decades of development and use. The Journal of Antimicrobial Chemotherapy, 51(90001 Suppl 1): 13–20Google Scholar
  17. Fick J, Söderström H, Lindberg R H, Phan C, Tysklind M, Larsson D G J (2009). Pharmaceuticals and personal care products in the environment contamination of surface, ground, and drinking water from pharmaceutical production. Environmental Toxicology and Chemistry, 28(12): 2522–2527Google Scholar
  18. Fu W, Fu J, Li X, Li B, Wang X (2018). Occurrence and fate of PPCPs in typical drinking water treatment plants in China. Environmental Geochemistry and HealthGoogle Scholar
  19. Gabarrón S, Gernjak W, Valero F, Barceló A, Petrovic M, Rodríguez-Roda I (2016). Evaluation of emerging contaminants in a drinking water treatment plant using electrodialysis reversal technology. Journal of Hazardous Materials, 309: 192–201Google Scholar
  20. Gao J, Huang J, Chen W, Wang B, Wang Y, Deng S, Yu G (2016). Fate and removal of typical pharmaceutical and personal care products in a wastewater treatment plant from Beijing: A mass balance study. Frontiers of Environmental Science & Engineering, 10(3): 491–501Google Scholar
  21. Gibs J, Stackelberg P E, Furlong E T, Meyer M, Zaugg S D, Lippincott R L (2007). Persistence of pharmaceuticals and other organic compounds in chlorinated drinking water as a function of time. Science of the Total Environment, 373(1): 240–249Google Scholar
  22. Houtman C J, Kroesbergen J, Lekkerkerker-Teunissen K, van der Hoek J P (2014). Human health risk assessment of the mixture of pharmaceuticals in Dutch drinking water and its sources based on frequent monitoring data. Science of the Total Environment, 496: 54–62Google Scholar
  23. Hu Y, Jiang L, Zhang T, Jin L, Han Q, Zhang D, Lin K, Cui C (2018). Occurrence and removal of sulfonamide antibiotics and antibiotic resistance genes in conventional and advanced drinking water treatment processes. Journal of Hazardous Materials, 360: 364–372Google Scholar
  24. Huang H,Wu J, Ye J, Ye T, Deng J, Liang Y, Liu W (2018). Occurrence, removal, and environmental risks of pharmaceuticals in wastewater treatment plants in south China. Frontiers of Environmental Science & Engineering, 12(6): 7Google Scholar
  25. Huber M M, Korhonen S, Ternes T A, von Gunten U (2005). Oxidation of pharmaceuticals during water treatment with chlorine dioxide. Water Research, 39(15): 3607–3617Google Scholar
  26. Huerta-Fontela M, Galceran M T, Ventura F (2011). Occurrence and removal of pharmaceuticals and hormones through drinking water treatment. Water Research, 45(3): 1432–1442Google Scholar
  27. Jelic A, Gros M, Ginebreda A, Cespedes-Sánchez R, Ventura F, Petrovic M, Barcelo D (2011). Occurrence, partition and removal of pharmaceuticals in sewage water and sludge during wastewater treatment. Water Research, 45(3): 1165–1176Google Scholar
  28. Kuchta S L, Cessna A J (2009). Lincomycin and spectinomycin concentrations in liquid swine manure and their persistence during simulated manure storage. Archives of Environmental Contamination and Toxicology, 57(1): 1–10Google Scholar
  29. Kuroda K, Nakada N, Hanamoto S, Inaba M, Katayama H, Do A T, Nga T T V, Oguma K, Hayashi T, Takizawa S (2015). Pepper mild mottle virus as an indicator and a tracer of fecal pollution in water environments: comparative evaluation with wastewater-tracer pharmaceuticals in Hanoi, Vietnam. Science of the Total Environment, 506–507: 287–298Google Scholar
  30. Lee Y, von Gunten U (2010). Oxidative transformation of micropollutants during municipal wastewater treatment: Comparison of kinetic aspects of selective (chlorine, chlorine dioxide, ferrate VI, and ozone) and non-selective oxidants (hydroxyl radical). Water Research, 44(2): 555–566Google Scholar
  31. Li L, Sun J, Liu B, Zhao D, Ma J, Deng H, Li X, Hu F, Liao X, Liu Y (2013). Quantification of lincomycin resistance genes associated with lincomycin residues in waters and soils adjacent to representative swine farms in China. Frontiers in Microbiology, 4: 1–9Google Scholar
  32. Li N, Ho K W K, Ying G G, Deng W J (2017). Veterinary antibiotics in food, drinking water, and the urine of preschool children in Hong Kong. Environment International, 108: 246–252Google Scholar
  33. Lin T, Yu S, Chen W (2016). Occurrence, removal and risk assessment of pharmaceutical and personal care products (PPCPs) in an advanced drinking water treatment plant (ADWTP) around Taihu Lake in China. Chemosphere, 152: 1–9Google Scholar
  34. Luo Y, Xu L, Rysz M, Wang Y, Zhang H, Alvarez P J J (2011). Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the Haihe River Basin, China. Environmental Science & Technology, 45(5): 1827–1833Google Scholar
  35. Ma R, Wang B, Yin L, Zhang Y, Deng S, Huang J, Wang Y, Yu G (2017). Characterization of pharmaceutically active compounds in Beijing, China: Occurrence pattern, spatiotemporal distribution and its environmental implication. Journal of Hazardous Materials, 323(Pt A): 147–155Google Scholar
  36. Mompelat S, Le Bot B, Thomas O (2009). Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water. Environment International, 35(5): 803–814Google Scholar
  37. Padhye L P, Yao H, Kung’u F T, Huang C H (2014). Year-long evaluation on the occurrence and fate of pharmaceuticals, personal care products, and endocrine disrupting chemicals in an urban drinking water treatment plant. Water Research, 51: 266–276Google Scholar
  38. Sarmah A K, Meyer M T, Boxall A B A (2006). A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere, 65(5): 725–759Google Scholar
  39. Schwab B W, Hayes E P, Fiori J M, Mastrocco F J, Roden N M, Cragin D, Meyerhoff R D D, D’Aco V J, Anderson P D (2005). Human pharmaceuticals in US surface waters: A human health risk assessment. Regulatory Toxicology and Pharmacology: RTP, 42(3): 296–312Google Scholar
  40. Sharma B M, Beèanová J, Scheringer M, Sharma A, Bharat G K, Whitehead P G, Klánová J, Nizzetto L (2019). Health and ecological risk assessment of emerging contaminants (pharmaceuticals, personal care products, and artificial sweeteners) in surface and groundwater (drinking water) in the Ganges River Basin, India. Science of the Total Environment, 646: 1459–1467Google Scholar
  41. Soufan M, Deborde M, Delmont A, Legube B (2013). Aqueous chlorination of carbamazepine: kinetic study and transformation product identification. Water Research, 47(14): 5076–5087Google Scholar
  42. Stackelberg P E, Furlong E T, Meyer M T, Zaugg S D, Henderson A K, Reissman D B (2004). Persistence of pharmaceutical compounds and other organic wastewater contaminants in a conventional drinking-water- treatment plant. Science of the Total Environment, 329(1–3): 99–113Google Scholar
  43. Stackelberg P E, Gibs J, Furlong E T, Meyer M T, Zaugg S D, Lippincott R L (2007). Efficiency of conventional drinking-water-treatment processes in removal of pharmaceuticals and other organic compounds. Science of the Total Environment, 377(2–3): 255–272Google Scholar
  44. Sui Q, Huang J, Deng S, Chen W, Yu G (2011). Seasonal variation in the occurrence and removal of pharmaceuticals and personal care products in different biological wastewater treatment processes. Environmental Science & Technology, 45(8): 3341–3348Google Scholar
  45. Sui Q, Huang J, Deng S, Yu G, Fan Q (2010). Occurrence and removal of pharmaceuticals, caffeine and DEET in wastewater treatment plants of Beijing, China. Water Research, 44(2): 417–426Google Scholar
  46. Tanoue R, Nomiyama K, Nakamura H, Hayashi T, Kim J W, Isobe T, Shinohara R, Tanabe S (2014). Simultaneous determination of polar pharmaceuticals and personal care products in biological organs and tissues. Journal of Chromatography. A, 1355: 193–205Google Scholar
  47. Tröger R, Klöckner P, Ahrens L, Wiberg K (2018). Micropollutants in drinking water from source to tap- Method development and application of a multiresidue screening method. Science of the Total Environment, 627: 1404–1432Google Scholar
  48. USEPA (2007). Method 1694: Pharmaceuticals and Personal Care Products in Water, Soil, Sediment, and Biosolids by HPLC/MS/MS. Washington DC: US Environmental Protection AgencyGoogle Scholar
  49. Verlicchi P, Al Aukidy M, Galletti A, Petrovic M, Barceló D (2012). Hospital effluent: investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment. Science of the Total Environment, 430: 109–118Google Scholar
  50. Vieno N, Tuhkanen T, Kronberg L (2007a). Elimination of pharmaceuticals in sewage treatment plants in Finland. Water Research, 41(5): 1001–1012Google Scholar
  51. Vieno N M, Härkki H, Tuhkanen T, Kronberg L (2007b). Occurrence of pharmaceuticals in river water and their elimination in a pilot-scale drinking water treatment plant. Environmental Science & Technology, 41(14): 5077–5084Google Scholar
  52. Wang C, Shi H, Adams C D, Gamagedara S, Stayton I, Timmons T, Ma Y (2011). Investigation of pharmaceuticals in Missouri natural and drinking water using high performance liquid chromatography-tandem mass spectrometry. Water Research, 45(4): 1818–1828Google Scholar
  53. Wu C, Huang X, Witter J D, Spongberg A L, Wang K, Wang D, Liu J (2014). Occurrence of pharmaceuticals and personal care products and associated environmental risks in the central and lower Yangtze river, China. Ecotoxicology and Environmental Safety, 106: 19–26Google Scholar
  54. Yang G C C, Yen C H, Wang C L (2014). Monitoring and removal of residual phthalate esters and pharmaceuticals in the drinking water of Kaohsiung City, Taiwan. Journal of Hazardous Materials, 277: 53–61Google Scholar
  55. Yang Y, Ok Y S, Kim K H, Kwon E E, Tsang Y F (2017). Occurrences and removal of pharmaceuticals and personal care products (PPCPs) in drinking water and water/sewage treatment plants: A review. Science of the Total Environment, 596–597: 303–320Google Scholar
  56. Yassine M H, Rifai A, Hoteit M, Mazellier P, Al Iskandarani M (2017). Study of the degradation process of ofloxacin with free chlorine by using ESI-LCMSMS: Kinetic study, by-products formation pathways and fragmentation mechanisms. Chemosphere, 189: 46–54Google Scholar
  57. Ye Z, Deng Y, Lou Y, Ye X, Chen S (2018). Occurrence of veterinary antibiotics in struvite recovery from swine wastewater by using a fluidized bed. Frontiers of Environmental Science & Engineering, 12(3): 7Google Scholar
  58. Zhang Q Q, Ying G G, Pan C G, Liu Y S, Zhao J L (2015). Comprehensive evaluation of antibiotics emission and fate in the river basins of China: Source analysis, multimedia modeling, and linkage to bacterial resistance. Environmental Science & Technology, 49(11): 6772–6782Google Scholar
  59. Zhang Y,Wang B, Cagnetta G, Duan L, Yang J, Deng S, Huang J, Wang Y, Yu G (2018). Typical pharmaceuticals in major WWTPs in Beijing, China: Occurrence, load pattern and calculation reliability. Water Research, 140: 291–300Google Scholar
  60. Zhao Y, Kong F, Wang Z, Yang H, Wang X, Xie Y F, Waite T D (2017). Role of membrane and compound properties in affecting the rejection of pharmaceuticals by different RO/NF membranes. Frontiers of Environmental Science & Engineering, 11(6): 20Google Scholar
  61. Zheng S, Qiu X, Chen B, Yu X, Liu Z, Zhong G, Li H, Chen M, Sun G, Huang H, Yu W, Freestone D (2011). Antibiotics pollution in Jiulong River estuary: Source, distribution and bacterial resistance. Chemosphere, 84(11): 1677–1685Google Scholar

Copyright information

© Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Xinshu Jiang
    • 1
  • Yingxi Qu
    • 1
  • Liquan Liu
    • 1
  • Yuan He
    • 1
    • 2
  • Wenchao Li
    • 1
  • Jun Huang
    • 1
    Email author
  • Hongwei Yang
    • 1
    • 2
  • Gang Yu
    • 1
  1. 1.School of Environment, Beijing Key Laboratory for Emerging Organic Contaminants ControlTsinghua UniversityBeijingChina
  2. 2.Research Institute for Environmental Innovation (Suzhou)Tsinghua, SuzhouChina

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