Journal of Central South University of Technology

, Volume 13, Issue 6, pp 608–612 | Cite as

Preparation of high viscosity average molecular mass poly-L-lactide

  • Zhou Zhi-hua  (周智华)
  • Ruan Jian-ming  (阮建明)Email author
  • Zou Jian-peng  (邹俭鹏)
  • Zhou Zhong-cheng  (周忠诚)
  • Shen Xiong-jun  (申雄军)


Poly-L-lactide(PLLA) was synthesized by ring-opening polymerization from high purity L-lactide with tin octoate as initiator, and characterized by means of infrared, and 1H-nuclear magnetic resonance. The influences of initiator concentration, polymerization temperature and polymerization time on the viscosity average molecular mass of PLLA were investigated. The effects of different purification methods on the concentration of initiator and viscosity average molecular mass were also studied. PLLA with a viscosity average molecular mass of about 50.5×104 was obtained when polymerization was conducted for 24 h at 140 °C with the molar ratio of monomer to purification initator being 12 000. After purification, the concentration of tin octoate decreases; however, the effect of different purification methods on the viscosity average molecular mass of PLLA is different, and the obtained PLLA is a typical amorphous polymeric material. The crystallinity of PLLA decreases with the increase of viscosity average molecular mass.

Key words

poly-L-lactide polymerization purification high viscosity average molecular mass 

CLC number



Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Agrawal C M, Ray R B. Biodegradable polymeric scaffolds for musculoskeletal tissue engineering[J]. J Biomed Mater Res, 2001, 55(2): 141–150.CrossRefGoogle Scholar
  2. [2]
    Niederauer G G, Slivka M A, Leatherbury N C, et al. Evaluation of multiphase implants for repair of focal osteochondral defects in goats[J]. Biomaterials, 2000, 21(24): 2561–2571.CrossRefGoogle Scholar
  3. [3]
    Middleton J C, Tipton A J. Synthetic biodegradable polymers as orthopaedic devices[J]. Biomaterials, 2000, 21(23): 2335–2346.CrossRefGoogle Scholar
  4. [4]
    Nakamura P, Hitomi S, Watanabe S, et al. Bioabsorption of polylactides with different molecular properties[J]. J Biomed Mater Res, 1989, 23(10): 1115–1130.CrossRefGoogle Scholar
  5. [5]
    Li S M, McCarthy S. Further investigations on hydrolytic degradation of poly (DL-lactide)[J]. Biomaterials, 1999, 20(1): 35–44.CrossRefGoogle Scholar
  6. [6]
    Tsuji H, Nakahara K, Ikarashi K. Poly(L-Lactide):part 8. High temperature hydrolysis of poly(L-lactide) films with different crystallinities and crystalline thickness in phosphate-buffered solution[J]. Macromol Mater Eng, 2001, 286(7): 398–406.CrossRefGoogle Scholar
  7. [7]
    Duek E R, Zavaglia C A, Belangero W D. In vitro study of poly(lactic acid) pin degradation[J]. Polymer, 1999, 40(23): 6465–5473.CrossRefGoogle Scholar
  8. [8]
    Taddei P, Tinti A, Fini G. Vibrational spectroscopy of polymeric biomaterials[J]. J Raman Spectrosc, 2001, 32(8): 619–629.CrossRefGoogle Scholar
  9. [9]
    Li S M, Garreau H, Vert M. Structure-property relationships in the case of the degradation of massive poly(a-hydroxy acids) in aqueous media, part 3: Influence of the morphology of poly(L-lactic acid)[J]. J Mater Sci: Mater Med, 1990, 1(3): 198–206.Google Scholar
  10. [10]
    ZHANG Hai-po, RUAN Jian-ming, ZHOU Zhong-cheng et al. Preparation of degradable biomaterial poly (L-lactide) monomer. Journal of Central South University of Technology, 2005, 12(3): 113–117.Google Scholar
  11. [11]
    Sosnowski S. Poly(L-lactide) microspheres with controlled crystallinity[J]. Polymer, 2001, 42(2): 637–643.CrossRefGoogle Scholar
  12. [12]
    Sakaia W, Sadakanea T, Nishimotoa W, et al. Photosensitized degradation and crosslinking of linear aliphatic polyesters studied by GPC and ESR[J]. Polymer, 2002, 43(23): 6231–6238.CrossRefGoogle Scholar
  13. [13]
    ZHOU Zhong-cheng, RUAN Jian-ming, HUANG Bai-yun, et al. Preparation and characterization of poly (D,L-lactide) and its porous biomaterials[J]. Journal of Central South University of Technology, 2005, 12(1): 1–4.CrossRefGoogle Scholar
  14. [14]
    HU Yu-shan, ZHANG Zheng-pu, SONG Dong, et al. Preparation and properties of self-reinforced L-and D, L-lactide copolymer rods[J]. Chinese Chemical Letters, 2000, 11(11): 1023–1026,.Google Scholar
  15. [15]
    Weir N A, Buchanana F J, Orra J F. Processing, annealing and sterilization of poly-L-lactide[J]. Biomaterials, 2004, 25(18): 3939–3949.CrossRefGoogle Scholar
  16. [16]
    Kang Moo Huh, You Han Bae. Synthesis and characterization of poly(ethylene glycol)/poly(L-lactic acid) alternating multiblock copolymers[J]. Polymer, 1999, 40(22): 6147–6155.CrossRefGoogle Scholar
  17. [17]
    Mandelkern L. The crystalline state in physical properties of polymers[M]. Washington DC: American Chemical Society, 1984: 176–190.Google Scholar

Copyright information

© Published by: Central South University Press, Sole distributor outside Mainland China: Springer 2006

Authors and Affiliations

  • Zhou Zhi-hua  (周智华)
    • 1
    • 2
  • Ruan Jian-ming  (阮建明)
    • 1
    Email author
  • Zou Jian-peng  (邹俭鹏)
    • 1
  • Zhou Zhong-cheng  (周忠诚)
    • 1
  • Shen Xiong-jun  (申雄军)
    • 1
  1. 1.State Key Laboratory of Powder MetallurgyCentral South UniversityChangshaChina
  2. 2.College of Chemistry and Chemical EngineeringHunan University of Science and TechnologyXiangtanChina

Personalised recommendations