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IL-1B, IL-6 and TNF-a change of experimental knee joint degeneration model and effect of local loosening therapy

  • Zhang Ying Email author
  • Zhou Jiang-nan 
  • Li Jia-bang 
  • Zhou Jing-cai 
  • Zhou Zhong-huan 
Medicine
  • 32 Downloads

Abstract

Objective To observe IL-1B, IL-6 and TNF-a level change of the joint fluid in the experimental knee joint degeneration and the effect of the local loosening therapy. Methods Thirty rabbits were divided into 3 groups at random: ten in the normal contrast group, ten in the blank model group and ten in the loosening therapy group to observe the IL-1B, IL-6 and TNF-a change of the joint fluid before and after the treatment in each group. Result IL-1B, IL-6 and TNF-a level in the blank model group was obviously higher than that in the normal group. (P<0.05). IL-1B, IL-6 and TNF-a level in the treatment group was obviously lower than that in the normal group. (P<0.05). Conclusions 1) IL-1B, IL-6 and TNF-a level of the joint fluid in the blank model group was obviously higher than that in the normal group. 2) Loosening soft tissues of the knees can improve IL-1B, IL-6 and TNF-a level of the joint fluid.

Key words

experimental knee joint degeneration local loosening therapy 

CLC number

R332 

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References

  1. [1]
    Langensh I A. OA of the knee in the rabbit produced By IZ[J]. Acta Orthop Scand, 1979, 50: 1–5.Google Scholar
  2. [2]
    WANG Gui-sheng. Experimental research on the rabbit’s knee joint cartilage degeneration caused by braking[J]. Journal of Chinese Surgery, 1987, 25(3): 175–177. (in Chinese)Google Scholar
  3. [3]
    Eroner I. GAG metabolism in experimental osteoarthrosis caused By IA[J]. Acta Orthop Scand, 1978, 49: 329–332.CrossRefGoogle Scholar
  4. [4]
    Chin J E, Lin Y A. Effects of recombinant human interleukin-1Bon rabbit articular chondrocytes[J]. Arthritis Rheum, 1988, 31: 1290–1296.CrossRefGoogle Scholar
  5. [5]
    Yocum D E, Esparza L, Dubry S, et al. Characteristics of tumor necrosis factor production in rheumatoid arthritis[J]. Cell Immunol, 1989, 122: 131–145.CrossRefGoogle Scholar
  6. [6]
    Guerne P A, Zuaraw B L, Varghan J H, et al. Synovium as a source of interleukin-6 in vitro contribution to local and systemic manifestations of arthritis[J]. J Chin Invest, 1989, 83: 585–588.CrossRefGoogle Scholar
  7. [7]
    Houssiau F A, Devogelaer J Y, Van Damme J, et al. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides[J]. Arthritis Rheum, 1988, 31: 784–788.CrossRefGoogle Scholar
  8. [8]
    WANG Xiu-yi, HU Nai-wu, WANG Wen-qiang, et al. Clinical research on treating senile OA by using closed loosening and deblocking methods as their principal therapies[A]. International Needle Blade Medical Forum[C]. 2003: 370–373.Google Scholar
  9. [9]
    ZHANG Ying, LI Jia-bang, ZHOU Jiang-nan. Knee joint degeneration model and effect of the local loosening therapy[J]. Journal of Chinese Medical Engineering, 2004, 12(5): 38–42. (in Chinese)Google Scholar

Copyright information

© Central South University 2005

Authors and Affiliations

  • Zhang Ying 
    • 1
    Email author
  • Zhou Jiang-nan 
    • 1
  • Li Jia-bang 
    • 1
  • Zhou Jing-cai 
    • 1
  • Zhou Zhong-huan 
    • 2
  1. 1.Institute of Integrated Traditional and Western Medicine, Xiangya HospitalCentral South UniversityChangshaChina
  2. 2.Zhonghuan ClinicCentre of Traditional MedicineWuchangChina

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