Induction of immune tolerance with heart-thymus composite allotransplantation in rats
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Objective To study on the role of thymus transplantation for heart allograft in rats. Methods Vascularized heart-thymus combined transplantation was performed with microsurgical technique. Graft survival, histopathology, level of IL-2, IL-4 and its mRNA expression in serum and cardiac grafts were investigated. Results Heart-thymus combined transplantation achieved effect in the prolongation of cardiac graft survival with short-term administration of cyclosporine. Conclusions Vascularized thymus transplantation induced immune tolerance in thymectomized rats.
Key wordsthymus transplantation immune tolerance rejection rat
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- XIONG Hai-bo, XIA Sui-sheng, WEN Hao. The establishment and improvement of method of thymectomy in rats[J]. Chinese Journal of Organ Transplantation, 2004, 25(4): 214. (in Chinese)Google Scholar
- Behrens D, Lange K, Fried A, et al. Donor-derived soluble MHC antigens plus low-dose cyclosporine induce transplantation unresponsiveness independent of the thymus by down-regulating T cell-mediated alloresponses in a rat transplantation model[J]. Transplantation, 2001, 72(12): 1974–1982.CrossRefGoogle Scholar
- Yamada K, Ierino F L, Gianello P R, et al. Role of the thymus in transplantation tolerance in miniature swine. III. surgical manipulation of the thymus interferes with stable induction of tolerance to class I-mismatched renal allografts[J]. Transplantation, 1999, 67(8): 1112–1119.CrossRefGoogle Scholar