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Preparation and characterization of poly(D,L-lactide) and its porous biomaterials

  • Zhou Zhong-cheng 
  • Ruan Jian-ming 
  • Huang Bai-yun 
  • Li Ya-jun 
  • Zou Jian-peng 
  • Zhang Hai-bo 
Article

Abstract

Poly(D,L-lactide) was synthesized by indirect method from D,L-lactic acid and characterized by infrared spectrum and proton nuclear magnetic resonance. The influences of monomer purity, initiator concentration, polymerization temperature and polymerization time on the relative molecular mass of poly(D, L-lactide) were investigated. The polylactide was made into porous materials by using solvent-casting particulate-leaching method. Under the optimized conditions, polylactides with a viscosity average molecular mass up to 1.82 × 105 are obtained and the results are fairly reproducible. Scanning electron microscope observation indicates that the sample is highly porous and well-distributed with good interconnections between pores and the pore size of porous materials is in the range from 200 µm to 500 µm and it can be used as scaffold for bone tissue engineering.

Key words

lactide polylactic acid tissue engineering scaffold 

CLC number

O633.14 

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Copyright information

© Central South University 2005

Authors and Affiliations

  • Zhou Zhong-cheng 
    • 1
  • Ruan Jian-ming 
    • 1
  • Huang Bai-yun 
    • 1
  • Li Ya-jun 
    • 1
  • Zou Jian-peng 
    • 1
  • Zhang Hai-bo 
    • 1
  1. 1.State Key Laboratory of Power MetallurgyCentral South UniversityChangshaChina

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