Journal of Central South University of Technology

, Volume 12, Issue 6, pp 693–698 | Cite as

Synthesis of o-L-α-glycerylphosphoryl-L-serine

  • Tang Rui-ren Email author
  • Yan Zi-er 
  • Luo Yi-ming 


A new efficient method for preparing o-L-α-glycerylphosphoryl-L-serine was presented. D-α, β-isopropylidene glycerol was phosphorylated with phenylphosphoryl dichloride and the resulting o-D-α,β-isopropylidene glycerylphenylphosphoryl chloride was esterified with N-tert-butoxycarbonyl-L-serine ethyl ester in the presence of pyridine to give acetone L-α-glycerylphenylphosphoryl-N-tert-butoxycarbonyl-L-serine ethyl ester. Finally, the protective groups were removed by two-step hydrolysis while strictly controlling pH value. The reaction to produce (1, 2), (5, 6)-diisopropylidene-D-mannitol, which is the key precursor for the preparation of D-α, β-isopropylidene glycerol, was monitored by using gas chromatography-mass spectrometer in order to obtain an optimum yield of 65%. All compounds were characterized through elemental analysis, infrared spectra, 1H, 13C, 31P-nuclear magnetic resonance spectra and mass spectra.

Key words

o-L-α-glycerylphosphoryl-L-serine N-tert-butoxycarbonyl-L-serine ethyl ester D-α, β-isopropylidene glycerol 

CLC number



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© Central South University 2005

Authors and Affiliations

  1. 1.School of Chemistry and Chemical EngineeringCentral South UniversityChangshaChina

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