Feasibility and efficacy of a supervised exercise intervention in de-conditioned cancer survivors during the early survivorship phase: the PEACH trial
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This study aims to evaluate the feasibility and efficacy of an 8-week supervised exercise program in de-conditioned cancer survivors within 2–6 months of chemotherapy completion.
Participants were randomly assigned to an 8-week, twice-weekly, supervised aerobic exercise training regime (n = 23) or a usual care group (n = 20). Feasibility was assessed by recruitment rate, program adherence and participant feedback. The primary outcome was aerobic fitness assessed by the Modified Bruce fitness test at baseline (0 weeks), post-intervention (8 weeks) and at 3-month follow-up. Secondary outcomes included physical activity, waist circumference, fatigue and quality of life.
The recruitment rate was 81 % and adherence to the supervised exercise was 78.3 %. Meaningful differences in aerobic fitness between the exercise and usual care groups at both the 8-week [mean 3.0 mL kg−1 min−1 (95 % CI −1.1–7.0)] and 3-month follow-up [2.1 mL kg−1 min−1 (−2.3–6.6)] were found, although these differences did not achieve statistical significance (p values >0.14). Self-reported physical activity increased in the exercise group (EG) compared to the usual care group at both 8-week (p = 0.01) and 3-month follow-up (p = 0.03) and significant differences in favour of the EG were found for physical well-being at both the 8-week (p = 0.03) and 3-month follow-up (p = 0.04). Improvements in fatigue (p = 0.01), total quality of life plus fatigue (p = 0.04), and a composite physical functioning score (p = 0.01) at the 3-month follow-up were also found.
The PEACH trial suggests that 8 weeks of supervised aerobic exercise training was feasible and may improve aerobic fitness, fatigue and quality of life in de-conditioned cancer survivors during the early survivorship phase.
Implications for Cancer Survivors
Exercise interventions commenced in the early survivorship phase appear safe, feasible and may lead to improvements in QOL and fatigue.
KeywordsQuality of life Physical activity Fitness Fatigue Feasibility study Randomised controlled trial
- 6.Duijts SF, Faber MM, Oldenburg HS, van Beurden M, Aaronson NK. Effectiveness of behavioral techniques and physical exercise on psychosocial functioning and health-related quality of life in breast cancer patients and survivors—a meta-analysis. Psychooncology. 2011;20(2):115–26. doi:10.1002/pon.1728.PubMedCrossRefGoogle Scholar
- 10.Thorsen L, Skovlund E, Stromme SB, Hornslien K, Dahl AA, et al. Effectiveness of physical activity on cardiorespiratory fitness and health-related quality of life in young and middle-aged cancer patients shortly after chemotherapy. J Clin Oncol. 2005;23(10):2378–88. doi:10.1200/jco.2005.04.106.PubMedCrossRefGoogle Scholar
- 24.Walsh JM, Hussey J, Guinan E, O’Donnell D. 'Pragmatic randomized controlled trial of individually prescribed exercise versus usual care in a heterogeneous cancer survivor population': a feasibility study PEACH trial: prescribed exercise after chemotherapy. BMC Cancer. 2010;10:42. doi:10.1186/1471-2407-10-42.PubMedCrossRefGoogle Scholar
- 30.Glass S, Dwyer G. ACSM’s metabolic calculations handbook. 1st ed. Baltimore: Lippincott Williams and Wilkins; 2006.Google Scholar
- 31.McArdle WD, Katch FI, Katch FI. Essentials of exercise physiology. 4th ed: Lippincott Williams and Wilkins; 2010.Google Scholar
- 35.Ware JE, Snow KK, Kosinski M, Gandek B. SF-36 health survey. Manual and interpretation guide. Boston: The Health institute, New England Medical Center; 1993.Google Scholar
- 36.Ware JE, Kosinski M, Dewey JE. How to score Version Two of the SF-36 Health Survey. Lincoln: Quality Metric; 2000.Google Scholar
- 41.Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, et al. Physical activity and public health: updated recommendations for adults from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116:1081–93. doi:10.1161/CIRCULATIONAHA.107.185649.PubMedCrossRefGoogle Scholar
- 42.Godin G, Shephard RJ. A simple method to assess exercise behaviour in the community. Can J Appl Sports Sci. 1985;10:141–6.Google Scholar
- 43.Godin G, Shephard RJ. Godin Leisure-Time Exercise Questionnaire. Med Sci Sports Exerc. 1997;29 June Supplement:S36–S8.Google Scholar
- 55.Vallance JK, Courneya KS, Plotnikoff RC, Yasui Y, Mackey JR. Randomized controlled trial of the effects of print materials and step pedometers on physical activity and quality of life in breast cancer survivors. J Clin Oncol. 2007;25(17):2352–9. doi:10.1200/jco.2006.07.9988.PubMedCrossRefGoogle Scholar