Is it safe and efficacious for women with lymphedema secondary to breast cancer to lift heavy weights during exercise: a randomised controlled trial
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Resistance exercise has great potential to aid in the management of breast cancer-related lymphedema (BCRL); however, little is known regarding optimal exercise prescription. The pervasive view is that resistance exercise with heavy loads may be contraindicated, disregarding the dose–response relationship that exists between the load utilised in resistance exercise and the magnitude of structural and functional improvements. No previous research has examined various resistance exercise prescriptions for the management of BCRL. This study compared the effects of high load and low load resistance exercise on the extent of swelling, severity of symptoms, physical function and quality of life in women with BCRL.
Sixty-two women with a clinical diagnosis of BCRL (>5 % inter-limb discrepancy) were randomly assigned to a high-load resistance exercise (n = 22), low-load resistance exercise (n = 21) or usual care (n = 19) group. Participants in the experimental groups completed a 3-month moderate- to high-intensity resistance exercise program in which the load of the exercises was manipulated from 10–6 repetition maximum (75–85 % of one repetition maximum [1RM]) for the high-load group or from 20–15 repetition maximum (55–65 % 1RM) for the low-load group. Outcome measures included the extent of swelling in the affected arm, symptom severity, physical function and quality of life.
There were no differences between groups in the extent of affected arm swelling or severity of symptoms. The change in muscle strength, muscle endurance and quality of life–physical functioning was significantly greater in both high-load and low-load groups compared with the control group (p < 0.040). Change in quality of life–physical function was significantly associated with the change in symptom severity and muscle strength. No lymphedema exacerbations or other adverse events occurred during this trial.
Women with BCRL can safely lift heavy weights during upper body resistance exercise without fear of lymphedema exacerbation or increased symptom severity.
Implications for Cancer Survivors
Women with breast cancer-related lymphedema can be informed that appropriately prescribed and supervised upper body resistance exercise is safe and can aid in the management of lymphedema through improvements in physical function and quality of life.
KeywordsResistance exercise Weight-lifting Lymphedema Breast cancer Dose–response relationship
Prue Cormie is supported by the Cancer Council Western Australia Postdoctoral Research Fellowship. This trial was funded by the Edith Cowan University Early Career Research Scheme and the University of Canberra’s Deputy Vice-Chancellor of Research Fellowship Scheme.
Conflict of interest
The authors declare that they have no conflict of interest.
The authors declare that they have no conflict of interest. This research was supported by funding from Edith Cowan University and University of Canberra. Clinical trials registration ACTRN12610000788077.
- 10.Courneya KS, Friedenreich CM, editors. Physical activity and cancer. Recent results in cancer research. London: Springer; 2011.Google Scholar
- 21.McNeely ML, Campbell K, Ospina M, Rowe BH, Dabbs K, Klassen TP, et al. Exercise interventions for upper-limb dysfunction due to breast cancer treatment. Cochrane Database Syst Rev. 2010;6:76.Google Scholar
- 23.Liu CJ, Latham NK. Progressive resistance strength training for improving physical function in older adults. Cochrane Database Syst Rev. 2009;3:267.Google Scholar
- 24.Lieber RL. Skeletal muscle structure, function and plasticity: the physiological basis of rehabilitation. 3rd ed. Philadelphia: Lippincott Williams & Williams; 2010.Google Scholar
- 32.Singh NA, Stavrinos TM, Scarbek Y, Galambos G, Liber C, Fiatarone Singh MA. A randomized controlled trial of high versus low intensity weight training versus general practitioner care for clinical depression in older adults. J Gerontol A Biol Sci Med Sci. 2005;60(6):768–76.PubMedCrossRefGoogle Scholar
- 36.Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334–59.PubMedCrossRefGoogle Scholar
- 37.Borg G. Borg's perceived exertion and pain scales. Champaign, IL: Human Kinetics; 1998.Google Scholar
- 49.Cantarero-Villanueva I, Fernandez-Lao C, Diaz-Rodriguez L, Fernandez-de-Las-Penas C, Ruiz JR, Arroyo-Morales M. The handgrip strength test as a measure of function in breast cancer survivors: relationship to cancer-related symptoms and physical and physiologic parameters. Am J Phys Med Rehabil. 2012;91(9):774–82. doi: 10.1097/PHM.0b013e31825f1538.PubMedCrossRefGoogle Scholar
- 50.Galvao DA, Taaffe DR, Spry N, Joseph D, Newton RU. Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression therapy for prostate cancer without bone metastases: a randomized controlled trial. J Clin Oncol. 2010;28(2):340–7.PubMedCrossRefGoogle Scholar