Journal of Cancer Survivorship

, Volume 4, Issue 3, pp 274–278 | Cite as

Fertility in patients treated for testicular cancer

  • Erika Matos
  • Breda Škrbinc
  • Branko Zakotnik



Testicular cancer affects men mostly in their reproductive age with a cure rate over 90% and fertility is one of the main concerns of survivors. To further elucidate the question of fertility after treatment for testicular cancer, we performed a survey in patients treated in our institution.

Patients and methods

We sent a questionnaire to patients treated for testicular cancer at our institute from 1976 to 2002 (n = 490) of whom 297 (60.6%) responded. We considered the patients to have conserved fertility if they had children after treatment without assisted reproductive technologies.


Before treatment 119/297 (40.1%) of patients and after treatment 150/297 (50.5%) of patients tried to have children (p = 0.019). Of 119 patients who tried to have children before treatment for testicular cancer 98 (82.4%) succeeded and 74/150 (49.3%) were successful after treatment (p < 0.001). After treatment patients had 1–3 (median 1) children. The median time to birth of first child from diagnosis was 12 years. The post-treatment fatherhood in patients treated with surgery only (orchidectomy +/− retroperitoneal lymphnode dissection-RPLND) was 59%, in those with additional radiotherapy 68%, and chemotherapy 50% (p = 0.233). Fertility rate in patients where a non nerve sparing RPLND was performed was only 37%, 62% in patients with nerve sapring RPLND, and 77% in patients where RPLND was not performed (p < 0.0001).


Fertility rate after treatment for testicular cancer is reduced. From our data, the most important treatment modality that influences fertility is non nerve sparing RPLND that should be avoided whenever possible in order improve the quality of life our patients.


Testicular cancer Fertility Retroperitoneal lymph node dissection Chemotherapy Radiotherapy 



The study was partially supported by grant J3-8924-302-97 of the Ministry of Higher Education, Science and Technology of Republic Slovenia.

We acknowledge the contribution of our pensioned colleagues, M. Stanovnik, MD who treated most of the patients included in this study and B. Jereb, MD, PhD for establishing the registry for late effects of cancer treatment of children and young adults.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department for Medical OncologyInstitute of Oncology LjubljanaLjubljanaSlovenia

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