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Application of decellularized allograft for primary repair of congenital heart disease in Japan

  • Hideto Ozawa
  • Takayoshi Ueno
  • Masaki Taira
  • Koichi Toda
  • Toru Kuratani
  • Yoshiki Sawa
Case Report

Abstract

A 6-month-old infant with a double outlet right ventricle, doubly committed ventricular septal defect, and right ventricle outflow tract (RVOT) stenosis underwent intracardiac repair with RVOT reconstruction using a fresh decellularized allograft derived from a 1-year-old heart transplant recipient in Japan. Early postoperative evaluation via echocardiography and cardiac magnetic resonance imaging revealed that the pulmonary allograft and cardiac function were stable. This is the first case report on using a decellularized heart valve, which was resected from a heart transplant recipient, for primary repair of congenital heart disease in Japan.

Keywords

Congenital heart disease Tissue engineering Decellularization 

Notes

Acknowledgements

This work is supported by the Research on Decellularized Heart Valve for Clinical Application by the Japan Medical Association Center for Clinical Trials, and the Japan Agency for Medical Research and Development.

References

  1. 1.
    Neumann A, Sarikouch S, Breymann T, et al. Early systemic cellular immune response in children and young adults receiving decellularized fresh allograft for pulmonary valve replacement. Tissue Eng Part A. 2014;20:1003–11.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Iop L, Bonetti A, Naso F, et al. Decellularized allogeneic heart valves demonstrate self-regeneration potential after a long-term preclinical evaluation. PLoS One. 2014;18:e99593.CrossRefGoogle Scholar
  3. 3.
    Sarikouch S, Horke A, Tudorache I, et al. Decellularized fresh homografts for pulmonary valve replacement: a decade of clinical experience. Eur J Cardiothorac Surg. 2016;50:281–90.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Jashari R, Goffin Y, Vanderkelen A, et al. European homograft bank: 20 years of cardiovascular tissue banking and collaboration with transplant coordination in Europe. Transplant Proc. 2010;42:183–189.CrossRefPubMedGoogle Scholar
  5. 5.
    Cebotari S, Tudorache I, Ciubotaru A, et al. Use of fresh decellularized allografts for pulmonary valve replacement may reduce the reoperation rate in children and young adults: early report. Circulation. 2011;124:115–23.CrossRefGoogle Scholar
  6. 6.
    Brockbank KG, Schenke-Layland K, Greene ED, et al. Ice-free cryopreservation of heart valve allografts: better extracellular matrix preservation in vivo and preclinical results. Cell Tissue Bank. 2012;13:663–71.CrossRefPubMedGoogle Scholar

Copyright information

© The Japanese Association for Thoracic Surgery 2018

Authors and Affiliations

  1. 1.Department of Cardiovascular SurgeryOsaka University Graduate School of MedicineSuitaJapan

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