Application of decellularized allograft for primary repair of congenital heart disease in Japan

  • Hideto Ozawa
  • Takayoshi Ueno
  • Masaki Taira
  • Koichi Toda
  • Toru Kuratani
  • Yoshiki Sawa
Case Report


A 6-month-old infant with a double outlet right ventricle, doubly committed ventricular septal defect, and right ventricle outflow tract (RVOT) stenosis underwent intracardiac repair with RVOT reconstruction using a fresh decellularized allograft derived from a 1-year-old heart transplant recipient in Japan. Early postoperative evaluation via echocardiography and cardiac magnetic resonance imaging revealed that the pulmonary allograft and cardiac function were stable. This is the first case report on using a decellularized heart valve, which was resected from a heart transplant recipient, for primary repair of congenital heart disease in Japan.


Congenital heart disease Tissue engineering Decellularization 



This work is supported by the Research on Decellularized Heart Valve for Clinical Application by the Japan Medical Association Center for Clinical Trials, and the Japan Agency for Medical Research and Development.


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Copyright information

© The Japanese Association for Thoracic Surgery 2018

Authors and Affiliations

  1. 1.Department of Cardiovascular SurgeryOsaka University Graduate School of MedicineSuitaJapan

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