Advertisement

Two cases of air leak syndrome after bone marrow transplantation successfully treated by the pleural covering technique

  • Hidenori Kunou
  • Ryu Kanzaki
  • Tomohiro Kawamura
  • Takashi Kanou
  • Naoko Ose
  • Soichiro Funaki
  • Yasushi Shintani
  • Masato Minami
  • Meinoshin Okumura
Case Report
  • 21 Downloads

Abstract

Air leak syndrome (ALS) is a rare complication after bone marrow transplantation (BMT) and usually has a fatal outcome because of the high recurrence rate and treatment-refractory nature. A 32-year-old man with a history of BMT for acute lymphoblastic leukemia suffered from metachronous bilateral ALS. Bullectomy and the pleural covering procedure (PLC) were successfully performed for each side of the thorax. After surgery, no relapse of pneumothorax was seen for 2 years on the right side and for 1 year on the left side. A 38-year-old man with a history of BMT for acute myelogenous leukemia (AML) suffered from ALS at the thorax on the left side. Bullectomy and the PLC were successfully performed. After that no recurrence of left pneumothorax for 7 years. We experienced two cases of ALS after BMT successfully treated by the PLC. This technique may be a viable treatment option for future lung transplantation.

Keywords

Air leak syndrome Bone marrow transplantation Pleural covering procedure 

Notes

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest to declare.

Ethical approval

The study protocol was approved by the Ethical Review Board for Clinical Studies at Osaka University (control number 10026-3).

References

  1. 1.
    Kurihara M, Kataoka H, Ishikawa A, Endo R. Latest treatments for spontaneous pneumothorax. Gen Thorac Cardiovasc Surg. 2010;58(3):113–9.CrossRefGoogle Scholar
  2. 2.
    Bergeron A. Late-Onset Noninfectious Pulmonary Complications After Allogeneic Hematopoietic Stem Cell Transplantation. Clin Chest Med. 2017;38(2):249–62.CrossRefGoogle Scholar
  3. 3.
    Chen-Yoshikawa TF, Okumura M, Miyoshi S, Oto T, Date H, et al. Prognostic factors in lung transplantation after hematopoietic stem cell transplantation. Transplantation. 2018;102(1):154–61.CrossRefGoogle Scholar
  4. 4.
    Sakai R, Kanamori H, Nakaseko C, Yoshiba F, Fujimaki K, et al. Air-leak syndrome following allo-SCT in adult patients: report from the Kanto study group for cell therapy in Japan. Bone Marrow Transpl. 2011;46(3):379–84.CrossRefGoogle Scholar
  5. 5.
    Franquet T, Rodríguez S, Hernández JM, Martino R, Giménez A, et al. Air-leak syndromes in hematopoietic stem cell transplant recipients with chronic GVHD: high-resolution CT findings. J Thorac Imaging. 2007;22:335–40.CrossRefGoogle Scholar
  6. 6.
    Almoosa KF, Ryu JH, Mendez J, Huggins JT, Young LR, et al. Management of pneumothorax in lymphangioleiomyomatosis: effects on recurrence and lung transplantation complications. Chest. 2006;129:1274–81.CrossRefGoogle Scholar
  7. 7.
    Kurihara M, Mizobuchi T, Kataoka H, Sato T, Kumasaka T, et al. A Total Pleural Covering for Lymphangioleiomyomatosis Prevents Pneumothorax Recurrence. PLoS One. 2016;11(9).Google Scholar

Copyright information

© The Japanese Association for Thoracic Surgery 2019

Authors and Affiliations

  • Hidenori Kunou
    • 1
  • Ryu Kanzaki
    • 1
  • Tomohiro Kawamura
    • 1
  • Takashi Kanou
    • 1
  • Naoko Ose
    • 1
  • Soichiro Funaki
    • 1
  • Yasushi Shintani
    • 1
  • Masato Minami
    • 1
  • Meinoshin Okumura
    • 1
  1. 1.Department of General Thoracic SurgeryOsaka University Graduate School of MedicineSuitaJapan

Personalised recommendations