General Thoracic and Cardiovascular Surgery

, Volume 63, Issue 8, pp 446–452 | Cite as

A novel protocol for antibiotic prophylaxis based on preoperative kidney function in patients undergoing open heart surgery under cardiopulmonary bypass

  • Mizuho OdakaEmail author
  • Kenji Minakata
  • Hideaki Toyokuni
  • Kazuhiro Yamazaki
  • Atsushi Yonezawa
  • Ryuzo Sakata
  • Kazuo Matsubara
Original Article



This study aimed to develop and assess the effectiveness of a protocol for antibiotic prophylaxis based on preoperative kidney function in patients undergoing open heart surgery.


We established a protocol for antibiotic prophylaxis based on preoperative kidney function in patients undergoing open heart surgery. This novel protocol was assessed by comparing patients undergoing open heart surgery before (control group; n = 30) and after its implementation (protocol group; n = 31) at Kyoto University Hospital between July 2012 and January 2013.


Surgical site infections (SSIs) were observed in 4 control group patients (13.3 %), whereas no SSIs were observed in the protocol group patients (P < 0.05). The total duration of antibiotic use decreased significantly from 80.7 ± 17.6 h (mean ± SD) in the control group to 55.5 ± 14.9 h in the protocol group (P < 0.05). Similarly, introduction of the protocol significantly decreased the total antibiotic dose used in the perioperative period (P < 0.05). Furthermore, antibiotic regimens were changed under suspicion of infection in 5 of 30 control group patients, whereas none of the protocol group patients required this additional change in the antibiotic regimen (P < 0.05).


Our novel antibiotic prophylaxis protocol based on preoperative kidney function effectively prevents SSIs in patients undergoing open heart surgery.


Antibiotic prophylaxis Cardiopulmonary bypass Renal function Surgical site infection 


Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© The Japanese Association for Thoracic Surgery 2015

Authors and Affiliations

  • Mizuho Odaka
    • 1
    • 3
    Email author
  • Kenji Minakata
    • 2
  • Hideaki Toyokuni
    • 1
  • Kazuhiro Yamazaki
    • 2
  • Atsushi Yonezawa
    • 1
  • Ryuzo Sakata
    • 2
  • Kazuo Matsubara
    • 1
  1. 1.Department of Clinical Pharmacology and TherapeuticsKyoto University HospitalKyotoJapan
  2. 2.Department of Cardiovascular SurgeryKyoto University HospitalKyotoJapan
  3. 3.Department of Pharmacy, University Hospital of MedicineTokyo Medical and Dental UniversityTokyoJapan

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