General Thoracic and Cardiovascular Surgery

, Volume 64, Issue 3, pp 167–169

Detection of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung

  • Riichiroh Maruyama
  • Fujio Matsumura
  • Yuji Shibata
  • Hiroshi Takahashi
  • Hiroko Okabayashi
  • Sachiyo Kosai
  • Izumi Honda
  • Susumu Ohkawara
  • Mineharu Sugimoto
Case Report

DOI: 10.1007/s11748-014-0428-4

Cite this article as:
Maruyama, R., Matsumura, F., Shibata, Y. et al. Gen Thorac Cardiovasc Surg (2016) 64: 167. doi:10.1007/s11748-014-0428-4

Abstract

We herein present a rare case of ALK-positive pulmonary pleomorphic carcinoma in an octogenarian patient. A computed tomography scan of the thorax indicated a pulmonary nodule in the right upper lobe of an asymptomatic 87-year-old female. The surgical resection revealed that the disease was pleomorphic carcinoma with pathological T2aN0M0, stage IB. EML4-ALK was evaluated using immunohistochemistry and fluorescence in situ hybridization, and EGFR mutations were analyzed using the Cycleave method. While there were no EGFR mutations detected, she was positive for the ALK rearrangement. This is the first report of ALK rearrangement in an octogenarian patient with pleomorphic carcinoma of the lung.

Keywords

Anaplastic lymphoma kinase Gene rearrangement Fluorescence in situ hybridization Pleomorphic carcinoma Octogenarian 

Copyright information

© The Japanese Association for Thoracic Surgery 2014

Authors and Affiliations

  • Riichiroh Maruyama
    • 1
  • Fujio Matsumura
    • 2
  • Yuji Shibata
    • 2
  • Hiroshi Takahashi
    • 3
  • Hiroko Okabayashi
    • 3
  • Sachiyo Kosai
    • 3
  • Izumi Honda
    • 3
  • Susumu Ohkawara
    • 4
  • Mineharu Sugimoto
    • 3
  1. 1.Department of Thoracic SurgeryOmuta Tenryo HospitalOmutaJapan
  2. 2.Department of SurgeryOmuta Tenryo HospitalOmutaJapan
  3. 3.Department of Respiratory MedicineOmuta Tenryo HospitalOmutaJapan
  4. 4.Department of PathologyArao Municipal HospitalAraoJapan

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